Computational Systems Biology
Editors: McDermott, J., Samudrala, R., Bumgarner, R., Montgomery, K., Ireton, R. (Eds.)
Free Preview- Presents a broad range of topics related to computational systems biology, including mechanistic modeling, high-throughput data analysis, biological network analysis and data representation and management
- Provides a number of clearly described, detailed ‘recipes’ for analysis of systems data
- Supplies a number of alternative approaches to modeling similar types of data
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- About this book
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The recent confluence of high throughput methodology for biological data gathering, genome-scale sequencing, and computational processing power has driven a reinvention and expansion of the way we identify, infer, model, and store relationships between molecules, pathways, and cells in living organisms. In Computational Systems Biology, expert investigators contribute chapters which bring together biological data and computational and/or mathematical models of the data to aid researchers striving to create a system that provides both predictive and mechanistic information for a model organism. The volume is organized into five major sections involving network components, network inference, network dynamics, function and evolutionary system biology, and computational infrastructure for systems biology. As a volume of the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.
Comprehensive and up-to-date, Computational Systems Biology serves to motivate and inspire all those who wish to develop a complete description of a biological system.
- Reviews
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From the reviews: “The new volume of the Humana Press ‘Methods in Molecular Biology’ series, entitled ‘Computational Systems Biology,’ consists of 25 chapters authored by 57 specialists in the field. … This book contains a wide collection of methods that … gives a broad review of this fascinating and quickly developing field. … for a computational biologist, it is a fascinating read, a broad and comprehensive resource on the current methods and approaches.” (Borys Wróbel, Acta Biochimica Polonica, Vol. 56, December, 2009)
- Table of contents (24 chapters)
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Identification of cis-Regulatory Elements in Gene Co-expression Networks Using A-GLAM
Pages 3-22
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Structure-Based Ab Initio Prediction of Transcription Factor–Binding Sites
Pages 23-41
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Inferring Protein–Protein Interactions from Multiple Protein Domain Combinations
Pages 43-59
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Prediction of Protein–Protein Interactions: A Study of the Co-evolution Model
Pages 61-88
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Computational Reconstruction of Protein–Protein Interaction Networks: Algorithms and Issues
Pages 89-100
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Table of contents (24 chapters)
- Download Preface 1 PDF (79.4 KB)
- Download Sample pages 2 PDF (512.9 KB)
- Download Table of contents PDF (72.1 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Computational Systems Biology
- Editors
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- Jason McDermott
- Ram Samudrala
- Roger Bumgarner
- Kristina Montgomery
- Reneé Ireton
- Series Title
- Methods in Molecular Biology
- Series Volume
- 541
- Copyright
- 2009
- Publisher
- Humana Press
- Copyright Holder
- Humana Press
- Distribution Rights
- Distribution rights for India: Atlantic Pub. & Distr. (P) Ltd., New Delhi, India
- eBook ISBN
- 978-1-59745-243-4
- DOI
- 10.1007/978-1-59745-243-4
- Hardcover ISBN
- 978-1-58829-905-5
- Softcover ISBN
- 978-1-4939-5644-9
- Series ISSN
- 1064-3745
- Edition Number
- 1
- Number of Pages
- XVIII, 592
- Topics
