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Methods in Pharmacology and Toxicology

Drug Metabolism and Transport

Molecular Methods and Mechanisms

Editors: Lash, Lawrence H. (Ed.)

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  • ISBN 978-1-59259-832-8
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Hardcover 166,39 €
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About this book

Remarkable advances in molecular and cell biology and the development of novel in vitro model systems have greatly expanded our knowledge of the processes involved in metabolism and transport and led to numerous new therapeutic approaches. In Drug Metabolism and Transport: Molecular Methods and Mechanisms, well-established investigators describe their best experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low-molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy. The strategies detailed for transport phenomena cover the multidrug resistance proteins, the reduced folate carrier, the plasma membrane, and mitochondrial glutathione transporters, and can be applied to numerous other transport systems. Many chapters contain step-by-step methods for investigating metabolism and transport.
Insightful and broad-ranging, Drug Metabolism and Transport: Molecular Methods and Mechanisms offers novice and experienced investigators alike a highly useful compendium of key strategies and approaches to successful research on drug metabolism and transport pathways.

Reviews

"With the diverse subject matter and the wealth of information on techniques and research strategies there is likely to be something in this book to interest those from PhD students to more experienced researchers." -Newsletter of the British Toxicological Society

Table of contents (14 chapters)

Table of contents (14 chapters)

Buy this book

eBook 128,39 €
price for Spain (gross)
  • ISBN 978-1-59259-832-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
Softcover 166,39 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Drug Metabolism and Transport
Book Subtitle
Molecular Methods and Mechanisms
Editors
  • Lawrence H. Lash
Series Title
Methods in Pharmacology and Toxicology
Copyright
2005
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-832-8
DOI
10.1385/1592598323
Hardcover ISBN
978-1-58829-324-4
Softcover ISBN
978-1-61737-494-4
Series ISSN
1557-2153
Edition Number
1
Number of Pages
X, 388
Number of Illustrations
110 b/w illustrations
Topics

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