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Cancer Drug Discovery and Development

DNA Repair in Cancer Therapy

Editors: Panasci, Lawrence C., Alaoui-Jamali, Moulay A. (Eds.)

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  • ISBN 978-1-59259-735-2
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Hardcover 207,99 €
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Softcover 207,99 €
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  • ISBN 978-1-61737-480-7
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About this book

Because of drug resistance, currently available anticancer therapies-drugs, radiotherapy, and other biological agents-have limited efficacy in treating cancer. In DNA Repair in Cancer Therapy, leading cancer researchers and oncologists comprehensively review the many recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limit its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Inhibitors of such other DNA repair enzymes as PARP and DNA-PK, now under development and close to clinical trials, are also examined.
Comprehensive and cutting-edge, DNA Repair in Cancer Therapy surveys-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.

Reviews

...gives a comprehensive review of the modern status of the DNA repair field for cancer researchers and clinical practitioners and provides a solid basis for in-depth study of different areas in this field...The book is a timely publication with a significant intended audience that will be served well. The book is well planned, well written, comprehensive, and addresses recent findings in the field. -Doody's Health Sciences Book Review Journal

"...extensive and extremely detailed...a comprehensive review of DNA repair." - The Annals of Pharmacotherapy

"Comprehensive and cutting-edge, for both cancer researchers and practicing oncologists dealing with the hallmark 'relapse; or 'drug resistance' phenomena on a daily basis...." Tumori


Table of contents (15 chapters)

Table of contents (15 chapters)
  • Clinical Resistance to Alkylators

    Pages 1-7

    Leyland-Jones, Brian, MD

  • Role of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard and DNA Crosslinking Agents

    Pages 9-29

    Panasci, Lawrence C., MD (et al.)

  • Repair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic Drugs

    Pages 31-49

    McHugh, Peter J., DPhil (et al.)

  • Chemosensitization to Platinum-Based Anticancer Drugs

    Pages 51-71

    Jean-Claude, Bertrand J., PhD

  • Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumor Cells

    Pages 73-108

    Boldogh, Istvan, PhD (et al.)

Buy this book

eBook 166,59 €
price for Spain (gross)
  • ISBN 978-1-59259-735-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 207,99 €
price for Spain (gross)
  • ISBN 978-1-58829-298-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 207,99 €
price for Spain (gross)
  • ISBN 978-1-61737-480-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
DNA Repair in Cancer Therapy
Editors
  • Lawrence C. Panasci
  • Moulay A. Alaoui-Jamali
Series Title
Cancer Drug Discovery and Development
Copyright
2004
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-735-2
DOI
10.1007/978-1-59259-735-2
Hardcover ISBN
978-1-58829-298-8
Softcover ISBN
978-1-61737-480-7
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XI, 363
Number of Illustrations
50 b/w illustrations
Topics