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- About this book
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It has now become clear that a large number of diseases with very different pathologies share a common framework of protein misfolding, accompanied by degradation and/or aggregation of the misfolded proteins. In Protein Misfolding and Disease: Principles and Protocols, notable experts in conformational disease review the latest thinking about the molecular processes underlying these diseases and describe cutting-edge biochemical, genomic, cellular, and chemical laboratory techniques for studying their genesis and pathologies. The authors apply their carefully refined methods to a variety of metabolic and neurodegenerative disorders, as well as to the aging process. The techniques presented are broadly applicable in many diverse disease contexts and may be used in both diagnosis and detailed research on new treatment strategies. Each tried and proven protocol includes insightful background notes, lists of required equipment and reagents, step-by-step instructions, and tips on troubleshooting and on how to avoid known pitfalls.
Comprehensive and cutting-edge, Protein Misfolding and Disease: Principles and Protocols offers both novice and experienced researchers a solid theoretical grounding in conformational disease and a remarkable set of analytical methodologies for uncovering its characteristics and generating new therapeutic approaches. - Reviews
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"...a very sound book that provides a solid background in conformational disease and presents the reader with helpful experimental protocols for studying protein folding folding and misfolding." - Pharmaceutical Research
"...this book will be a very useful took for specialists in protein chemistry, molecular biology and basic medicine, and also for teachers and their students studying principles of proteomics." Biochemistry
- Table of contents (24 chapters)
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Protein Misfolding, Aggregation, and Degradation in Disease
Pages 3-16
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Basic Introduction to In Vivo Protein Folding and Its Defects
Pages 17-26
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Cystic Fibrosis
Pages 27-37
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α1-Antitrypsin Deficiency
Pages 39-56
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Parkinson’s Disease
Pages 57-66
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Table of contents (24 chapters)
- Download Preface 1 PDF (132.4 KB)
- Download Table of contents PDF (132.4 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Protein Misfolding and Disease
- Editors
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- Peter Bross
- Niels Gregersen
- Series Title
- Methods in Molecular Biology
- Series Volume
- 232
- Copyright
- 2003
- Publisher
- Humana Press
- Copyright Holder
- Humana Press
- eBook ISBN
- 978-1-59259-394-1
- DOI
- 10.1385/1592593941
- Hardcover ISBN
- 978-1-58829-065-6
- Softcover ISBN
- 978-1-61737-332-9
- Series ISSN
- 1064-3745
- Edition Number
- 1
- Number of Pages
- XV, 318
- Topics
