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Psychiatric Disorders

Methods and Protocols

  • Book
  • © 2019
  • Latest edition

Overview

Editors:
  1. Firas H. Kobeissy

    1. Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2011)

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About this book

This second edition volume expands on the previous edition with updates to chapters and new chapters discussing the latest research in neuropsychiatric diseases. The chapters in this book are organized into eleven sections and cover the diversity and utility of animal models of psychiatric disorders, their development, modelling, and pathophysiological and molecular profiles. Part One looks at experimental modeling of neuropsychiatric studies and the usefulness and need of animal models. Parts Two and Three focus on experimental models of neuropsychiatric illnesses, including self-injurious behavior, bipolar disorder, anxiety, and learning and decision-making testing. Parts Four and Five discuss animal models of substance abuse. Part Six describes protocols to examine animal models related to maladaptive eating habits and behaviors. Parts Seven and Eight cover neurodegenerative diseases stemming from natural causes (aging), abnormal genetic backgrounds, or those brought on by trauma. Part Nine talks about inflammatory and metabolic alteration profiles relevant to autism spectrum disorders and depression. Parts Ten and Eleven conclude the book with a discussion on genetics, epigenetics, and system biology in the field of psychiatric disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Psychiatric Disorders: Methods and Protocols, Second Edition is a useful resource for graduates, postdoctoral workers, and established scientists working in the fields of behavioral and molecular neuropsychiatric research.   

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Table of contents (40 protocols)

  1. Front Matter

    Pages i-xxiii
    Download chapter PDF

  2. Overview of the Animal Research in Psychiatric Illness

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development

      • Arie Kaffman, Jordon D. White, Lan Wei, Frances K. Johnson, John H. Krystal
      Pages 3-22

    3. Qualitative vs. Quantitative Methods in Psychiatric Research: Updated

      • A. Benjamin Srivastava, Firas H. Kobeissy, Mark S. Gold
      Pages 23-37

  3. Overview of Animal Models of Psychiatric Illness

    1. Front Matter

      Pages 39-39
      Download chapter PDF

    2. Animal Models of Self-Injurious Behavior: An Update

      • Darragh P. Devine
      Pages 41-60

    3. Bipolar Disorder: Its Etiology and How to Model in Rodents

      • Nadja Freund, Georg Juckel
      Pages 61-77

    4. Recent Updates in Modeling Risky Decision Making in Rodents

      • Caitlin A. Orsini, Shelby L. Blaes, Barry Setlow, Nicholas W. Simon
      Pages 79-92

  4. Methods of Animal Models of Psychiatric Illness

    1. Front Matter

      Pages 93-93
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    2. The Pemoline Model of Self-Injurious Behavior: An Update

      • Darragh P. Devine
      Pages 95-103

    3. Rodent Models of Adaptive Value Learning and Decision-Making

      • Alicia Izquierdo, Claudia Aguirre, Evan E. Hart, Alexandra Stolyarova
      Pages 105-119

    4. The Visually Mediated Social Preference Test: A Novel Technique to Measure Social Behavior and Behavioral Disturbances in Zebrafish

      • William H. J. Norton, Line Manceau, Florian Reichmann
      Pages 121-132

    5. Animal Models of Intoxication by Metal Elements: A Focus on Neurobehavioral Injuries

      • Abdellatif Abbaoui, Lahcen Tamegart, Halima Gamrani
      Pages 133-142

    6. Animal Models of Early-Life Adversity

      • Hajar Benmhammed, Samer El Hayek, Inssaf Berkik, Hicham Elmostafi, Rim Bousalham, Abdelhalem Mesfioui et al.
      Pages 143-161

  5. Overview of Animal Models of Substance Abuse

    1. Front Matter

      Pages 163-163
      Download chapter PDF

    2. Nicotine Self-Administration as Paradigm for Medication Discovery for Smoking Cessation: Recent Findings in Medications Targeting the Cholinergic System

      • Jose M. Trigo, Bernard Le Foll
      Pages 165-193

    3. The Human Laboratory and Drug Development in Alcohol Use Disorder: Recent Updates

      • Chidera C. Chukwueke, Bernard Le Foll
      Pages 195-219

    4. Rodent Models of Methamphetamine Misuse: Mechanisms of Methamphetamine Action and Comparison of Different Rodent Paradigms

      • Hiba Hasan, Samar Abdelhady, Muhammad Haidar, Christina Fakih, Samer El Hayek, Stefania Mondello et al.
      Pages 221-250

  6. Methods of Animal Models of Substance Abuse

    1. Front Matter

      Pages 251-251
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    2. Recent Updates in Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs

      • Brandon Levin, Isaac Wilks, Sijie Tan, Azin Behnood-Rod, Adriaan Bruijnzeel
      Pages 253-265
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Editors and Affiliations

  • Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

    Firas H. Kobeissy

Bibliographic Information

  • Book Title: Psychiatric Disorders

  • Book Subtitle: Methods and Protocols

  • Editors: Firas H. Kobeissy

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-9554-7

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2019

  • Hardcover ISBN: 978-1-4939-9553-0Published: 05 July 2019

  • Softcover ISBN: 978-1-4939-9556-1Published: 14 August 2020

  • eBook ISBN: 978-1-4939-9554-7Published: 04 July 2019

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XXIII, 728

  • Number of Illustrations: 17 b/w illustrations, 64 illustrations in colour

  • Topics: Neurosciences, Psychiatry

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