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Methionine Dependence of Cancer and Aging

Methods and Protocols

  • Book
  • © 2019

Overview

Editors:
  1. Robert M. Hoffman

    1. AntiCancer, Inc., San Diego, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1866)

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Table of contents (24 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Methods to Study the Role of Methionine-Restricted Diet and Methioninase in Cancer Growth Control

    • Shushma Chaturvedi, Joseph R. Bertino
    Pages 1-12

  3. Altered Methionine Metabolism in Cancer Cells

    • Robert M. Hoffman, Peter H. Stern, Dennis W. Coalson, C. Douglas Wallace, Richard W. Erbe
    Pages 13-26

  4. Linkage of Methionine Dependence and Other Features of Malignancy

    • Robert M. Hoffman, Richard W. Erbe
    Pages 27-36

  5. Isolation and Characterization of Methionine-Independent Clones from Methionine-Dependent Cancer Cells

    • Stacey L. Borrego, Da-Wei Lin, Peter Kaiser
    Pages 37-48

  6. Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction

    • Robert M. Hoffman, Shuya Yano
    Pages 49-60

  7. Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction

    • Elena Strekalova, Dmitry Malin, Harisha Rajanala, Vincent L. Cryns
    Pages 61-73

  8. Efficacy of Methionine-Restricted Diets on Cancers In Vivo

    • Robert M. Hoffman, Yasunori Hoshiya, Weiyan Guo
    Pages 75-81

  9. Dietary Methionine Restriction-Based Cancer Chemotherapy in Rodents

    • Robert M. Hoffman, Peter H. Stern
    Pages 83-94

  10. Clinical Studies of Methionine-Restricted Diets for Cancer Patients

    • Robert M. Hoffman
    Pages 95-105

  11. Development of Recombinant Methioninase for Cancer Treatment

    • Robert M. Hoffman, Yuying Tan, Shukuan Li, Qinghong Han, Shigeo Yagi, Tomoaki Takakura et al.
    Pages 107-131

  12. Methioninase Cell-Cycle Trap Cancer Chemotherapy

    • Robert M. Hoffman, Shuya Yano, Kentaro Igarashi
    Pages 133-148

  13. High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer

    • Robert M. Hoffman, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Yuying Tan, Shukuan Li et al.
    Pages 149-161

  14. Total Methionine Restriction Treatment of Cancer

    • Robert M. Hoffman, Demetrius M. Kokkinakis, Eugene P. Frenkel
    Pages 163-171

  15. Methioninase Gene Therapy

    • Robert M. Hoffman, Kenji Miki, Waddah Al-Refaie, Mingxu Xu, Yuying Tan
    Pages 173-197

  16. Selenomethionine and Methioninase: Selenium Free Radical Anticancer Activity

    • Julian E. Spallholz
    Pages 199-210

  17. Safety and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates

    • Robert M. Hoffman, Zhijian Yang, Yuying Tan, Qinghong Han, Shukuan Li, Shigeo Yagi
    Pages 211-229

  18. Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine

    • Robert M. Hoffman, Yuying Tan, Shukuan Li, Qinghong Han, Jorge Zavala Sr, Jorge Zavala Jr
    Pages 231-242

  19. Methionine Gamma Lyase from Clostridium sporogenes Increases the Anticancer Efficacy of Doxorubicin on A549 Cancer Cells In Vitro and Human Cancer Xenografts

    • V. S. Pokrovsky, N. Yu. Anisimova, D. Zh. Davydov, S. V. Bazhenov, N. V. Bulushova, G. B. Zavilgelsky et al.
    Pages 243-261

  20. Methionine Restriction and Life-Span Extension

    • Robert M. Hoffman
    Pages 263-266
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Keywords

About this book

This book explores the methionine dependence of cancer and its effects on aging, a great story of science that is not widely known. The chapters in this book describe the discovery of methionine dependence of cancer; the molecular basis for the increased methionine demand of cancer cells and tumors; the clinical application of methionine dependence of cancer in PET imaging with [11C]methionine; the development of methioninases as cancer drugs; the anti-aging and anti-diabetes effects of methionine restriction; and the future of targeting methionine in the body for the elimination of cancer and for the extension of a healthy life-span. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.


Cutting-edge and thorough, MethionineDependence of Cancer and Aging: Methods and Protocols is an important resource for researchers and scientists wishing to pursue this exciting and vital area of study."


Editors and Affiliations

  • AntiCancer, Inc., San Diego, USA

    Robert M. Hoffman

Bibliographic Information

  • Book Title: Methionine Dependence of Cancer and Aging

  • Book Subtitle: Methods and Protocols

  • Editors: Robert M. Hoffman

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-8796-2

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2019

  • Hardcover ISBN: 978-1-4939-8795-5Published: 07 February 2019

  • eBook ISBN: 978-1-4939-8796-2Published: 06 February 2019

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XII, 329

  • Number of Illustrations: 46 b/w illustrations, 34 illustrations in colour

  • Topics: Cancer Research

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