Editors:
- Novel theme: no other book is combining host-bacterial interaction and organoid systems in studying human diseases
- Multiple disciplinary: covers progress in host-microbiota interactions, using organoids, cell cultures, animal models, and human samples
- Broad audience: physiologists and students working on the inflammatory diseases, metabolic diseases, infectious diseases, cancers, and other human diseases will be most interested in this book. Gastroenterologists, pathologists, microbiologists, and immunologists will also have interests in this book
Part of the book series: Physiology in Health and Disease (PIHD)
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Table of contents (12 chapters)
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Front Matter
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Back Matter
About this book
Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes.
In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes.
Reviews
Editors and Affiliations
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Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, USA
Jun Sun, Pradeep K. Dudeja
About the editors
Dr. Pradeep K. Dudeja is a Professor of Physiology in Medicine at Univ. of Illinois at Chicago and a Senior Research Career Scientist at the Jesse Brown VA Medical Center, Chicago, IL, USA. His research primarily focuses on an understanding of the pathophysiology of diarrheal diseases and to develop better therapeutic interventions. Our focus has been on host-microbe interactions with respect to the mechanisms underlying infectious diarrhea as it relates to infections by a food-borne pathogen Enteropathogenic E. coli and diarrhea elicited by C. difficile infection. We are also investigating the mechanisms underlying antidiarrheal role of probiotics. Another focus of his group has been to understand the mechanisms of absorption of key bacterial metabolites: short chain fatty acids and their role in intestinal health in general and implications in gut fluid absorption and gut inflammation. Dr. Dudeja has published over 200 original peer reviewed articles in journals including Gastroenterology, J. Clin. Investigation, J. Inflammatory Bowel Diseases and Am. J. Physiol.. He serves as an Editor for Comprehensive Physiology and serves on the editorial board of many journals including Gastroenterology, AJP-GI-Liver, Digestive Diseases & Sciences and Physiological Reports. He has beenserving on many grant review committees including NIH and VA.
Bibliographic Information
Book Title: Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases
Editors: Jun Sun, Pradeep K. Dudeja
Series Title: Physiology in Health and Disease
DOI: https://doi.org/10.1007/978-1-4939-7534-1
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018
Hardcover ISBN: 978-1-4939-7533-4Published: 27 January 2018
Softcover ISBN: 978-1-4939-8513-5Published: 04 June 2019
eBook ISBN: 978-1-4939-7534-1Published: 26 January 2018
Series ISSN: 2625-252X
Series E-ISSN: 2625-2538
Edition Number: 1
Number of Pages: XVIII, 381
Number of Illustrations: 8 b/w illustrations, 26 illustrations in colour
Topics: Human Physiology, Medical Microbiology, Internal Medicine