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  • Reference work
  • © 2018

Pancreatic Cancer

  • Updated and revised edition featuring the latest advancements in pancreatic cancer and its treatment

  • Written by leading experts in their respective fields

  • Shows the growing impact of surgical approaches for recurrent cancer of the pancreas

  • Includes supplementary material: sn.pub/extras

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Table of contents (64 entries)

  1. Front Matter

    Pages i-xxxiii
  2. The Nature of Pancreatic Cancer

    1. Front Matter

      Pages 1-1
    2. Epidemiology and Prospects for Prevention of Pancreatic Cancer

      • Patrick Maisonneuve, Albert Lowenfels
      Pages 3-18
    3. Cell Cycle Machinery and Its Alterations in Pancreatic Cancer

      • Yusuke Kojima, Reeja S. Maskey, Yuichi J. Machida
      Pages 19-49
    4. Pathologic Classification and Biological Behavior of Pancreatic Neoplasia

      • Olca Basturk, Michelle D. Reid, N. Volkan Adsay
      Pages 51-87
    5. Developmental Molecular Biology of the Pancreas

      • L. Charles Murtaugh, Ondine Cleaver, Raymond J. MacDonald
      Pages 89-145
    6. The Molecular Pathology of Precursor Lesions of Pancreatic Cancer

      • Aatur D. Singhi, Anirban Maitra
      Pages 147-176
    7. Molecular Pathology of Pancreatic Endocrine Tumors

      • Gianfranco Delle Fave, Elettra Merola, Gabriele Capurso, Stefano Festa, Matteo Piciucchi, Roberto Valente
      Pages 209-239
    8. Sporadic Pancreatic Endocrine Tumors

      • Volker Fendrich, Detlef K. Bartsch
      Pages 241-263
    9. Molecular Pathology of Carcinomas of the Ampullary/Periampullary Region

      • Lena Haeberle, Jasmin Riemer, Irene Esposito
      Pages 265-281
    10. Miscellaneous Nonpancreatic Nonendocrine Tumors

      • Heather A. Lillemoe, John D. Abad, Keith D. Lillemoe
      Pages 283-312
    11. Animal Modeling of Pancreatitis-to-Cancer Progression

      • Paola Martinelli, Francisco X. Real
      Pages 313-347
    12. Pancreatic Cancer Stem Cells

      • Mackenzie Goodwin, Ethan V. Abel, Vinee Purohit, Diane M. Simeone
      Pages 349-368
    13. Apoptosis: Signaling Pathways in Pancreatic Cancer Pathogenesis

      • David J. McConkey, Woonyoung Choi
      Pages 369-382
    14. EGFR (ErbB) Signaling Pathways in Pancreatic Cancer Pathogenesis

      • Monique Williams, Gwen Lomberk, Raul Urrutia
      Pages 383-408
    15. Hedgehog Signaling Plays a Dual Role in Pancreatic Carcinogenesis

      • Tara L. Hogenson, Rachel L. O. Olson, Martin E. Fernandez-Zapico
      Pages 409-430
    16. Stromal Inflammation in Pancreatic Cancer: Mechanisms and Translational Applications

      • Kathleen A. Boyle, Michael A. James, Susan Tsai, Douglas B. Evans, Michael B. Dwinell
      Pages 481-508

About this book

In organizing the second edition of  this renowned Handbook, Dr. Neoptolemos and his co-editors have produced and updated a revised edition to the distinguished Major Reference Work devoted to pancreatic cancer. Like its preceding edition, the second edition continues to have a widespread appeal among clinicians, pathologists and basic scientists, who are now struggling to understand this complex and rapidly expanding field. Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer, (there is currently an unprecedented investment by academia and industry in this field), each research’s knowledge of other specialty areas outside his or her own is often quite limited. The aim of the new edition is to place the tangible advances, including new developments in surgical approaches with regards to resection techniques, the state of laparoscopic approaches, the growing impact of surgical approaches in the management of recurrent pancreatic cancer, controversies in the management of IMPN as the precursor lesion for PDAC and others – readily at hand. The second edition focuses on advances that will not become dated, and the editors have chosen authors, who are the very best in each area.

Editors and Affiliations

  • Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany

    John P. Neoptolemos, Markus W. Büchler

  • Division of Research Department of Surgery and Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, USA

    Raul Urrutia

  • Division of Medical Oncology, Duke Cancer Institute, Duke University Medical Center, Durham, USA

    James L. Abbruzzese

About the editors

John Neoptolemos is Professor of Surgery and Head of the Division of Surgery and Oncology at the University of Liverpool and Honorary Consultant Surgeon at the Royal Liverpool University Hospital. As an undergraduate he studied Natural Sciences at Cambridge (BA 1973, MA 1976) before completing his clinical undergraduate training at Guys Hospital (Cambridge: MB, BChir 1976). He completed his academic and clinical training in Leicester under Prof. Sir Peter Bell, being awarded a Doctorate in Medicine in 1986.

Raul A. Urrutia, M.D., Mayo Clinic College of Medicine, Rochester, MN USA. Dr. Urrutia was awarded his M.D., Magna Cum Laude, by the University of Cordoba, Argentina.

Dr. James L. Abbruzzese is the Chairman of the Department of Gastrointestinal Medical Oncology at the University of Texas M. D. Anderson Cancer Center, Houston, Texas, where he holds the Annie Laurie Howard Research Distinguished Professorship. Author of over 150 original articles and book chapters, Dr. Abbruzzese has recently been appointed the Editor-in-Chief of the International Journal of Pancreatology. He serves on the editorial board of a number of prestigious journals, including the Journal of Clinical Oncology and Clinical Cancer Research, and also serves on the Scientific Advisory Board of the Lustgarten Foundation for Pancreatic Cancer Research.

Markus W. Büchler is Professor of Surgery at the University of Heidelberg, Germany. He studied medicine at the Universities of Heidelberg and Berlin and was trained in surgery at the Department of Surgery, University of Ulm, where he was appointed a Consultant Surgeon in 1987 and Vice Chairman in 1991. Professor Büchler is a specialist in hepato-pancreato-biliary surgery (HPB) and, in particular, pancreatic surgery. He has a substantial curriculum of scientific publications in the field of HPB diseases, especially in translational research of pancreatic cancer. He is Editor or Editorial Board member of many leading journals in general and gastrointestinal surgery, translational and molecular research in pancreatology and other gastrointestinal diseases, including Annals of Surgery, British Journal of Surgery. Digestive Surgery (Editor), Pancreas, Langenbeck's Archive of Surgery (Editor), HPB, and Surgery.

Bibliographic Information

  • Book Title: Pancreatic Cancer

  • Editors: John P. Neoptolemos, Raul Urrutia, James L. Abbruzzese, Markus W. Büchler

  • DOI: https://doi.org/10.1007/978-1-4939-7193-0

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Reference Module Biomedical and Life Sciences

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018

  • Hardcover ISBN: 978-1-4939-7191-6Published: 12 April 2018

  • eBook ISBN: 978-1-4939-7193-0Published: 11 April 2018

  • Edition Number: 2

  • Number of Pages: XXXIII, 1661

  • Number of Illustrations: 67 b/w illustrations, 177 illustrations in colour

  • Topics: Cancer Research, Oncology, Endocrinology

Buy it now

Buying options

eBook USD 849.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 1,099.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access