Overview
- Includes cutting-edge methods and protocols on GPCRs in drug discovery
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 1335)
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About this book
This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.
Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets.
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Keywords
Table of contents (20 protocols)
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Front Matter
Editors and Affiliations
Bibliographic Information
Book Title: G Protein-Coupled Receptors in Drug Discovery
Book Subtitle: Methods and Protocols
Editors: Marta Filizola
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-4939-2914-6
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2015
Hardcover ISBN: 978-1-4939-2913-9Published: 11 August 2015
Softcover ISBN: 978-1-4939-4967-0Published: 21 February 2018
eBook ISBN: 978-1-4939-2914-6Published: 10 August 2015
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 2
Number of Pages: XII, 327
Number of Illustrations: 21 b/w illustrations, 50 illustrations in colour
Topics: Pharmacology/Toxicology, Proteomics