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The Receptors

Extrasynaptic GABAA Receptors

Editors: Errington, Adam C., Di Giovanni, Giuseppe, Crunelli, Vincenzo (Eds.)

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  • First book to describe tonic inhibition
  • Emphasizes the important role of extrasynaptic GABAA receptors
  • Brings together contributions from leading experts in the field
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eBook 117,69 €
price for Spain (gross)
  • ISBN 978-1-4939-1426-5
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Hardcover 155,99 €
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  • ISBN 978-1-4939-1425-8
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Softcover 145,78 €
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  • ISBN 978-1-4939-5321-9
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About this book

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Reviews

“This is an excellent monograph on the subject of GABA neurotransmission and GABA receptors in the synaptic and postsynaptic regions. … I highly recommend this book for neuroscientists, and neurophysiologists in an academic setting. It is of use for students, fellows, and postdoctoral scholars.” (Joseph J. Grenier, Amazon.com, May, 2015)


Table of contents (13 chapters)

Table of contents (13 chapters)

Buy this book

eBook 117,69 €
price for Spain (gross)
  • ISBN 978-1-4939-1426-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-1-4939-1425-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 145,78 €
price for Spain (gross)
  • ISBN 978-1-4939-5321-9
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Extrasynaptic GABAA Receptors
Editors
  • Adam C. Errington
  • Giuseppe Di Giovanni
  • Vincenzo Crunelli
Series Title
The Receptors
Series Volume
27
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4939-1426-5
DOI
10.1007/978-1-4939-1426-5
Hardcover ISBN
978-1-4939-1425-8
Softcover ISBN
978-1-4939-5321-9
Series ISSN
1048-6909
Edition Number
1
Number of Pages
IX, 295
Number of Illustrations
16 b/w illustrations, 18 illustrations in colour
Topics

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