Extrasynaptic GABAA Receptors
Editors: Errington, Adam C., Di Giovanni, Giuseppe, Crunelli, Vincenzo (Eds.)
Free Preview- First book to describe tonic inhibition
- Emphasizes the important role of extrasynaptic GABAA receptors
- Brings together contributions from leading experts in the field
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- About this book
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GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.
- Reviews
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“This is an excellent monograph on the subject of GABA neurotransmission and GABA receptors in the synaptic and postsynaptic regions. … I highly recommend this book for neuroscientists, and neurophysiologists in an academic setting. It is of use for students, fellows, and postdoctoral scholars.” (Joseph J. Grenier, Amazon.com, May, 2015)
- Table of contents (13 chapters)
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Extrasynaptic GABAA Receptors
Pages 1-14
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Extrasynaptic GABAA Receptors: Subunit Composition, Distribution, and Regulation
Pages 15-32
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Biophysical Properties of Recombinant γ2- and δ-subunit Containing GABAA Receptors
Pages 33-50
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The Pharmacology of Extrasynaptic GABAA Receptors
Pages 51-74
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Neurosteroids and Extrasynaptic GABAA Receptors
Pages 75-84
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Table of contents (13 chapters)
- Download Preface 1 PDF (706.7 KB)
- Download Sample pages 1 PDF (960.2 KB)
- Download Table of contents PDF (707.5 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Extrasynaptic GABAA Receptors
- Editors
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- Adam C. Errington
- Giuseppe Di Giovanni
- Vincenzo Crunelli
- Series Title
- The Receptors
- Series Volume
- 27
- Copyright
- 2014
- Publisher
- Springer-Verlag New York
- Copyright Holder
- Springer Science+Business Media, LLC
- eBook ISBN
- 978-1-4939-1426-5
- DOI
- 10.1007/978-1-4939-1426-5
- Hardcover ISBN
- 978-1-4939-1425-8
- Softcover ISBN
- 978-1-4939-5321-9
- Series ISSN
- 1048-6909
- Edition Number
- 1
- Number of Pages
- IX, 295
- Number of Illustrations
- 16 b/w illustrations, 18 illustrations in colour
- Topics
