- Presents updated contemporary classification systems of myeloid leukemias, their genetic defects and the proteomic alterations characteristic of acute myeloid leukemia
- Summarizes and interprets targeted in acute myeloid therapies, along with future therapeutics
- Serves as a useful guideline to scientists, translational researchers and clinicians in the field
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- About this book
-
This book provides an unprecedented overview of "Targeted Therapies" for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies round up this overview of the multi-dimensional therapeutic landscape in which leukemia specialists develop treatment strategies that are expected to make "leukemia history" in the near future.
- Table of contents (44 chapters)
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Genetics and Classification of Acute Myeloid Leukemia
Pages 1-25
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The Use of “Omics” to Guide the Selection of Targeted Therapy
Pages 27-43
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Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML
Pages 47-65
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Bcl-2 Family: Translational Aspects
Pages 67-94
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IAP Family of Proteins as Therapeutic Targets for Acute Myeloid Leukemia
Pages 95-121
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Table of contents (44 chapters)
- Download Preface 1 PDF (998.6 KB)
- Download Sample pages 1 PDF (1.2 MB)
- Download Table of contents PDF (1,011.9 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Targeted Therapy of Acute Myeloid Leukemia
- Editors
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- Michael Andreeff
- Series Title
- Current Cancer Research
- Copyright
- 2015
- Publisher
- Springer-Verlag New York
- Copyright Holder
- Springer-Verlag New York
- eBook ISBN
- 978-1-4939-1393-0
- DOI
- 10.1007/978-1-4939-1393-0
- Hardcover ISBN
- 978-1-4939-1392-3
- Softcover ISBN
- 978-1-4939-3989-3
- Series ISSN
- 2199-2584
- Edition Number
- 1
- Number of Pages
- XIX, 826
- Number of Illustrations
- 16 b/w illustrations, 46 illustrations in colour
- Topics
