Interactomics and Systems Biology

The Molecular Chaperones Interaction Networks in Protein Folding and Degradation

Editors: Houry, Walid A. (Ed.)

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  • First book in the Interactomics and Systems Biology book series?
  • Provides a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones
  • Discusses their role in cell stress responses and in diseases from a global network perspective
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eBook 117,69 €
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  • ISBN 978-1-4939-1130-1
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Hardcover 207,99 €
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  • ISBN 978-1-4939-1129-5
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Softcover 155,50 €
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About this book

Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion.  

In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases.

This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective. ​  

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Table of contents (17 chapters)

Table of contents (17 chapters)

Buy this book

eBook 117,69 €
price for Spain (gross)
  • ISBN 978-1-4939-1130-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 207,99 €
price for Spain (gross)
  • ISBN 978-1-4939-1129-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 155,50 €
price for Spain (gross)
  • ISBN 978-1-4939-4864-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
The Molecular Chaperones Interaction Networks in Protein Folding and Degradation
Editors
  • Walid A. Houry
Series Title
Interactomics and Systems Biology
Series Volume
1
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-1130-1
DOI
10.1007/978-1-4939-1130-1
Hardcover ISBN
978-1-4939-1129-5
Softcover ISBN
978-1-4939-4864-2
Edition Number
1
Number of Pages
XV, 485
Number of Illustrations
8 b/w illustrations, 54 illustrations in colour
Topics