Genotoxicity and DNA Repair
A Practical Approach
Editors: Sierra, L. María, Gaivão, Isabel (Eds.)
Free Preview- Focuses on key assays in genotoxicity and DNA repair
- Places special emphasis on the analysis of nanoparticles and nanomaterials
- Features reproducible techniques and expert implementation advice
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- About this book
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Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the “OECD guidelines for the testing of chemicals”, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.
Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study.
- Table of contents (25 chapters)
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Ames Test (Bacterial Reverse Mutation Test): Why, When, and How to Use
Pages 3-22
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The Ames II and Ames MPF Penta I Assay: A Liquid Microplate Format Modification of the Classic Ames Test
Pages 23-41
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Revised Procedure of the Bacterial Reverse Mutation Test for Genotoxic Evaluation of Nanoparticles
Pages 43-58
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The Control of Hydrophobic Compound Exposure in In Vitro Tests for Genotoxicity
Pages 59-72
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The In Vitro Micronucleus Assay and FISH Analysis
Pages 73-102
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Table of contents (25 chapters)
- Download Preface 1 PDF (62.9 KB)
- Download Sample pages 1 PDF (676.1 KB)
- Download Table of contents PDF (115.1 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Genotoxicity and DNA Repair
- Book Subtitle
- A Practical Approach
- Editors
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- L. María Sierra
- Isabel Gaivão
- Series Title
- Methods in Pharmacology and Toxicology
- Copyright
- 2014
- Publisher
- Humana Press
- Copyright Holder
- Springer Science+Business Media New York
- eBook ISBN
- 978-1-4939-1068-7
- DOI
- 10.1007/978-1-4939-1068-7
- Hardcover ISBN
- 978-1-4939-1067-0
- Softcover ISBN
- 978-1-4939-4829-1
- Series ISSN
- 1557-2153
- Edition Number
- 1
- Number of Pages
- XII, 483
- Number of Illustrations
- 28 b/w illustrations, 42 illustrations in colour
- Topics
