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Advances in Experimental Medicine and Biology

Steroid Hormone Resistance

Mechanisms and Clinical Aspects

Editors: Chrousos, George P., Loriaux, D. Lynn, Lipsett, Mortimer B. (Eds.)

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About this book

This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones. Glucocorticoids, mineralocorticoids, androgens, estrogens, progesterone and vitamin D have widely diverse roles ranging from the control of homeostasis to reproduction and bone formation. They are similar in that they share a chemical structure and that their action is in the cell nucleus where they induce transcription of specific genes leading to synthesis of function-specific proteins. Clinical syndromes of steroid hormone resistance to androgens (complete and partial testicular feminization), aldosterone (pseudo­ hypoaldosteronism) and vitamin D (vitamin D-dependent rickets type II) have been known for many years. Progesterone and glucocorticoid resistance syndromes have been described only recently. Resistance to estrogens has not been reported in man or in animals. It is hoped that a detailed reexamination of what is known about each of these conditions at the clinical and molecular levels will enhance our understanding of the function of these hormones and their mechanisms of action. New insight and research initiatives should result. G.P. Chrousos D.L. Loriaus M.B. Lipsett vii ACKNOWLEDGMENTS The contents of this volume are based in part on the proceedings of an International Conference held in Bethesda in the summer of 1984. This conference was sponsored by the National Institute of Child Health and Human Development, Bethesda, Maryland.

Table of contents (28 chapters)

Table of contents (28 chapters)

Buy this book

eBook 96,29 €
price for Spain (gross)
  • ISBN 978-1-4684-5101-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 124,79 €
price for Spain (gross)
  • ISBN 978-1-4684-5103-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Steroid Hormone Resistance
Book Subtitle
Mechanisms and Clinical Aspects
Editors
  • George P. Chrousos
  • D. Lynn Loriaux
  • Mortimer B. Lipsett
Series Title
Advances in Experimental Medicine and Biology
Series Volume
196
Copyright
1986
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-5101-6
DOI
10.1007/978-1-4684-5101-6
Softcover ISBN
978-1-4684-5103-0
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIII, 439
Topics

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