Skip to main content
SpringerLink
Log in

Narcotic Drugs

Biochemical Pharmacology

  • Book
  • © 1971

Overview

Editors:
  1. Doris H. Clouet

    1. New York State Research Institute for Neurochemistry and Drug Addiction, New York, USA
      Narcotic Addiction Control Commission, New York, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (26 chapters)

  1. Front Matter

    Pages i-xxii
    Download chapter PDF

  2. The Chemistry of Narcotic Analgesic Drugs

    1. The Structure of Narcotic Analgesic Drugs

      • Alan F. Casy
      Pages 1-16

    2. Methods of Chemical Analysis

      • John F. Taylor
      Pages 17-88

    3. Structure-Activity Relationships

      • Louis S. Harris
      Pages 89-98

  3. The Metabolic Disposition of Narcotic Analgesic Drugs

    1. Physiological Disposition of Narcotic Agonists and Antagonists

      • Salvatore J. Mulé
      Pages 99-121

    2. Transport in the Central Nervous System

      • Carl C. Hug Jr.
      Pages 122-136

    3. Biotransformations

      • Joseph T. Scrafani, Doris H. Clouet
      Pages 137-158

  4. The Effects of Narcotic Analgesic Drugs on General Metabolic Systems

    1. Intermediary and Energy Metabolism

      • A. E. Takemori
      Pages 159-189

    2. Phospholipid Metabolism

      • Salvatore J. Mulé
      Pages 190-215

    3. Protein and Nucleic Acid Metabolism

      • Doris H. Clouet
      Pages 216-228

  5. The Effects of Narcotic Analgesic Drugs on Specific Systems

    1. Catecholamines and 5-Hydroxytryptamine

      • E. Leong Way, Fu-Hsiung Shen
      Pages 229-253

    2. Acetylcholine and Cholinesterase

      • Marta Weinstock
      Pages 254-261

    3. Corticosteroid Hormones

      • Jewell W. Sloan
      Pages 262-282

    4. Hypothalamus: Anterior Pituitary Gland

      • Robert George
      Pages 283-299

    5. Inorganic Ions: The Role of Calcium

      • Hiroshi Kaneto
      Pages 300-309

  6. Sites of Action of Narcotic Analgesic Drugs

    1. Single Cells

      • Eric J. Simon
      Pages 310-341

    2. The Nervous System

      • Herbert L. Borison
      Pages 342-365

    3. The Kidney

      • James M. Fujimoto
      Pages 366-393

    4. Peripheral Tissues

      • Marta Weinstock
      Pages 394-407

  7. Tolerance and Dependence

    1. Tolerance and Physical Dependence

      • Louis Shuster
      Pages 408-423
Back to top

Keywords

About this book

The riddle of the biochemical nature of drug dependence of the opiate type has stimulated many studies directed toward understanding the molecular basis of the action of opiates, and, particularly, the phenomena of tolerance, physical dependence, and drug-seeking behavior-phenomena exhibited by man and experimental animals exposed persistently to these drugs. The results of these studies provided a substantial body of information which has been published in the scientific and medical literature. The purely pharma­ cological responses in man and animals to the opiates have been described and evaluated in many monographs and text-books of pharmacology. However, there is no single source for specific and detailed information on the responses of the body and its tissues to narcotic analgesic drugs at the level of biochemical pharmacology; that is, the molecular history of the drug in the body and the biochemical consequences of its presence in tissue. This volume has been prepared in an effort to repair the deficiency. Two factors have contributed a special urgency to making this infor­ mation available in convenient form: (1) the current need for a better under­ standing of the biochemical mechanisms underlying addiction to narcotic drugs, and (2) the progress made in molecular biology which promises that significant advances in the elucidation of fundamental processes in the central nervous system and their drug-induced aberrations may soon be possible.

Editors and Affiliations

  • New York State Research Institute for Neurochemistry and Drug Addiction, New York, USA

    Doris H. Clouet

  • Narcotic Addiction Control Commission, New York, USA

    Doris H. Clouet

Bibliographic Information

  • Book Title: Narcotic Drugs

  • Book Subtitle: Biochemical Pharmacology

  • Editors: Doris H. Clouet

  • DOI: https://doi.org/10.1007/978-1-4684-1869-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1971

  • Softcover ISBN: 978-1-4684-1871-2Published: 30 March 2012

  • eBook ISBN: 978-1-4684-1869-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXII, 506

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Biochemical Engineering

Publish with us

Policies and ethics

Back to top

Search

Navigation