Cell Death in Biology and Diseases

Necrotic Cell Death

Editors: Shen, Han-Ming, Vandenabeele, Peter (Eds.)

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  • Examines several forms of necrotic cell death, including necroptosis, autophagic cell death, and PARP-mediated cell death
  • Discusses the effect of necrotic cell death on metabolism, inflammation, immunity, and development
  • Explores the relevance of necrotic cell death to human diseases
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eBook 118,99 €
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  • ISBN 978-1-4614-8220-8
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Hardcover 166,39 €
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  • ISBN 978-1-4614-8219-2
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  • Usually dispatched within 3 to 5 business days.
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Softcover 155,50 €
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  • ISBN 978-1-4939-4402-6
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  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

About the authors

Dr. Han-Ming Shen is currently Associate Professor in the Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore. He received his Ph.D. from the National University of Singapore and holds a Master of Medicine from Zhejiang Medical University, China. Winner of several academic and scientific awards, Dr. Shen’s main research interests include autophagy in cell death and cancer, involvement of reactive oxygen/nitrogen species and oxidative stress in cell death signaling pathways (apoptotic and non-apoptotic cell death), and antioxidants and natural products as anti-cancer agents.

Dr. Peter Vandenabeele obtained his PhD in Biology in the lab of Prof. Walter Fiers at Ghent University in Belgium. Currently, he is a Primary Investigator at the Flanders Institute for Biotechnology (VIB) and a Senior Professor at Ghent University where he also served for ten years as Director of the Bachelor’s and Master’s program in Biochemistry and Biotechnology and still serves on the Board of Governors.  His research focuses on molecular mechanisms of cell death and inflammation with focus on necrotic cell death which is studied in an integrated way at biochemical, cell biological and experimental disease level. Dr. Vandenabeele has also twice been chairman of the Euroconference on Apoptosis, organized by the European Cell Death Organization (ECDO).

Table of contents (18 chapters)

Table of contents (18 chapters)

Buy this book

eBook 118,99 €
price for Spain (gross)
  • ISBN 978-1-4614-8220-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
  • ISBN 978-1-4614-8219-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 155,50 €
price for Spain (gross)
  • ISBN 978-1-4939-4402-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Necrotic Cell Death
Editors
  • Han-Ming Shen
  • Peter Vandenabeele
Series Title
Cell Death in Biology and Diseases
Copyright
2014
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8220-8
DOI
10.1007/978-1-4614-8220-8
Hardcover ISBN
978-1-4614-8219-2
Softcover ISBN
978-1-4939-4402-6
Series ISSN
2625-2902
Edition Number
1
Number of Pages
XIV, 397
Number of Illustrations
5 b/w illustrations, 39 illustrations in colour
Topics