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  • © 2013

Next Generation Sequencing in Cancer Research

Volume 1: Decoding the Cancer Genome

  • Applies the Next Generation Sequencing (NGS) technology to practical and real cancer research projects?

  • Each chapter will briefly cover the outline for bioinformatic analysis

  • The primary audience are researchers and scientists in cancer biology, molecular biology, and other related areas in biomedical research

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xii
  2. The Evolution of High-Throughput Sequencing Technologies: From Sanger to Single-Molecule Sequencing

    • Chee-Seng Ku, Yudi Pawitan, Mengchu Wu, Dimitrios H. Roukos, David N. Cooper
    Pages 1-30
  3. Next-Generation Sequencing in Cancer Epigenomics and Potential Clinical Applications

    • Hong Kiat Ng, Dimitrios H. Roukos, Barry Iacopetta, Chee-Seng Ku
    Pages 31-53
  4. Next-Generation Sequencing for Cancer Genomics

    • Aarti N. Desai, Abhay Jere
    Pages 55-74
  5. Genomic Landscape of Cancer Metastasis

    • Arvind K. Singla, Chandini Thirukkumaran, Rajiv Dixit, Wei Wu
    Pages 75-90
  6. Mapping the HIF Transcription Factor in Cancer by ChIP-Seq Technology

    • Johannes Schödel, David R. Mole
    Pages 91-117
  7. Application of Next-Generation Sequencing to Analysis of TGFβ/SMAD4 Targets in Ovarian Cancer

    • Russell Bonneville, Kenneth Nephew, Victor X. Jin
    Pages 119-135
  8. Targeted Sequencing Strategies in Cancer Research

    • HoJoon Lee, Billy T. Lau, Hanlee P. Ji
    Pages 137-163
  9. Comprehensive Genomic Alterations in Common Cancer Cell Lines Revealed by Exome Sequencing

    • Han Chang, Donald G. Jackson, Paul S. Kayne, Petra B. Ross-Macdonald, Rolf-Peter Ryseck, Nathan O. Siemers
    Pages 165-182
  10. MicroRNA Expression in Breast Cancer Revealed by Deep Sequencing Technology

    • Thalia A. Farazi, Carl S. Leonhardt, Thomas Tuschl
    Pages 233-261
  11. RNA-Seq in Prostate Cancer Research

    • ShanCheng Ren, Min Qu, Yinghao Sun
    Pages 263-286
  12. Next-Generation Sequencing for High-Throughput RNA Interference Screens

    • Toby M. Ward, Anna-Maria Jegg, Elizabeth Iorns
    Pages 287-299
  13. Tumor Phylogenetics in the NGS Era: Strategies, Challenges, and Future Prospects

    • Ayshwarya Subramanian, Stanley Shackney, Russell Schwartz
    Pages 335-357
  14. Impact and Challenges in Assessing Tumor Purity by Next-Generation Sequencing

    • Xiaoping Su, Gabriel G. Malouf, Francisco J. Esteva
    Pages 359-371
  15. Back Matter

    Pages 373-383

About this book

​​​​This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology. 

Editors and Affiliations

  • Dept. Pathology & Laboratory Medicine, University of Calgary, Calgary, Canada

    Wei Wu

  • The Wellcome Trust Centre for Human Gene, University of Oxford, Oxford, United Kingdom

    Hani Choudhry

Bibliographic Information

  • Book Title: Next Generation Sequencing in Cancer Research

  • Book Subtitle: Volume 1: Decoding the Cancer Genome

  • Editors: Wei Wu, Hani Choudhry

  • DOI: https://doi.org/10.1007/978-1-4614-7645-0

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-7644-3Published: 05 August 2013

  • Softcover ISBN: 978-1-4899-8808-9Published: 25 August 2015

  • eBook ISBN: 978-1-4614-7645-0Published: 04 August 2013

  • Edition Number: 1

  • Number of Pages: XII, 383

  • Topics: Cancer Research, Bioinformatics, Human Genetics, Biomedicine general

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access