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  • Reference work
  • © 2014

Handbook of Neurotoxicity

Editors:

  1. Richard M. Kostrzewa

    1. Department of Biomedical Sciences, East Tennessee State University, Johnson City, USA

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  • Major reference work

  • Contains detailed information on a wide number of topics

  • Features contributions from experts across the field

  • Includes supplementary material: sn.pub/extras

Sections

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Table of contents (97 entries)

  1. Front Matter

    Pages 1-38
    PDF

  2. Neurotoxins

    1. Front Matter

      Pages 1-1
      PDF

    2. Survey of Selective Neurotoxins

      • Richard M. Kostrzewa
      Pages 3-67

    3. Necroptosis, a Potential Therapeutic Target for Neurological Disorders

      • Jing Chen, Richard M. Kostrzewa, Xingshun Xu
      Pages 69-93

    4. RCSN Cell System for Identifying Dopaminergic Neurotoxicity

      • Pablo Caviedes, Raúl Caviedes, Juan Segura-Aguilar
      Pages 95-108

    5. Microglia: Neuroprotective and Neurodestructive Properties

      • G. Jean Harry, Christopher A. McPherson
      Pages 109-132

    7. Dopamine and L-dopa as Selective Endogenous Neurotoxins

      • Juan Segura-Aguilar, Ulises Ahumada-Castro, Irmgard Paris
      Pages 199-218

    8. Nature of DSP-4-Induced Neurotoxicity

      • Aleksandra Bortel
      Pages 219-236

    9. MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modeling of Parkinson’s Disease

      • Livia Pasquali, Elena Caldarazzo-Ienco, Francesco Fornai
      Pages 237-275

    10. Cocaine as a Neurotoxin

      • Teresa Cunha-Oliveira, A. Cristina Rego, Catarina R. Oliveira
      Pages 277-297

    11. 5,6- and 5,7-Dihydroxytryptamines as Serotoninergic Neurotoxins

      • Justyna Paterak, Roman Stefański
      Pages 299-325

    12. 2′-NH2-MPTP: A Serotonin and Norepinephrine Neurotoxin

      • Jason B. Ochroch, Amanda J. Bressler, Hongyan Yang, Dennis L. Murphy, Stefanie C. Altieri, Anne M. Andrews
      Pages 327-346

    14. Glutamate as a Neurotoxin

      • Gabrielle N. Turski, Chrysanthy Ikonomidou
      Pages 365-397

    15. Domoic Acid as a Neurotoxin

      • Anabel Pérez-Gómez, R. Andrew Tasker
      Pages 399-419

    16. Endogenous Kynurenic Acid and Neurotoxicity

      • Ewa M. Urbańska, Iwona Chmiel-Perzyńska, Adam Perzyński, Marek Derkacz, Björn Owe-Larsson
      Pages 421-453

    17. Neurotoxicity in Psychostimulant and Opiate Addiction

      • Ewa Niedzielska, Bartłomiej Rospond, Lucyna Pomierny-Chamioło, Anna Sadakierska-Chudy, Małgorzata Filip
      Pages 455-512

    18. Molecular Mechanism and Effects of Clostridial Neurotoxins

      • Bal Ram Singh, Raj Kumar, Shuowei Cai
      Pages 513-551

    19. Botulinum Neurotoxins as Therapeutics

      • Raja Mehanna, Joseph Jankovic
      Pages 553-590
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About this book

The Handbook of Neurotoxicity is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin’ is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction – akin to a neurotoxin’s effect. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.
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Editors and Affiliations

  • Department of Biomedical Sciences, East Tennessee State University, Johnson City, USA

    Richard M. Kostrzewa

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About the editor

Dr. Kostrzewa is professor of Pharmacology. He received his BS (1967) in Chemistry and MS (1967) in Pharmacology from Philadelphia College of Pharmacy and Science. He received his Ph.D. (1971) in Pharmacology from the University of Pennsylvania and was awarded Doctor Honoris Causa, 2005 from the Medical University of Silesia in Katowice Poland. Following his post-doctoral training in New Orleans he was appointed to the faculty at Louisiana State University. He joined the faculty in the department of Pharmacology at ETSU in 1978, rising to the rank of Professor in 1984. Dr. Kostrzewa is a world recognized authority in the neuropharmacological aspects of Parkinson Disease and ADHD, with a primary focus on Serotoninergic, histaminergic and dopaminergic systems. 
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Bibliographic Information

  • Book Title: Handbook of Neurotoxicity

  • Editors: Richard M. Kostrzewa

  • DOI: https://doi.org/10.1007/978-1-4614-5836-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Reference Module Biomedical and Life Sciences

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4614-5835-7Published: 04 June 2014

  • eBook ISBN: 978-1-4614-5836-4Published: 03 June 2014

  • Edition Number: 1

  • Number of Pages: XXXVIII, 2371

  • Number of Illustrations: 97 b/w illustrations, 147 illustrations in colour

  • Topics: Neurosciences

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Buy it now

eBook USD 549.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

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