Mucosal Immunology of Acute Bacterial Pneumonia

1. Front Matter

   Pages i-x

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2. Alveolar Macrophages

   • David H. Dockrell, Paul J. Collini, Helen M. Marriott

   Pages 1-48

3. Lung Dendritic Cells and Pulmonary Defence Mechanisms to Bacteria

   • Bart N. Lambrecht, Katrijn Neyt, Corine H. GeurtsvanKessel, Hamida Hammad

   Pages 49-66

4. CD4 T-Cell Immunity in the Lung

   • Jay K. Kolls

   Pages 67-82

5. Neutrophils in Acute Bacterial Pneumonia

   • John C. Gomez, Qin Wang, Claire M. Doerschuk

   Pages 83-124

6. Toll-Like Receptors in the Airway Epithelium

   • Shawn J. Skerrett

   Pages 125-138

7. Type I Interferon Responses to Airway Pathogens

   • Dane Parker

   Pages 139-158

8. Transcriptional Signaling Hubs in Epithelial Cells During Pneumonia

   • Lee J. Quinton, Joseph P. Mizgerd

   Pages 159-183

9. Innate Immune Responses in Ventilator-Associated Pneumonia

   • Megan N. Ballinger, Theodore J. Standiford

   Pages 185-212

10. Streptococcus pneumoniae: The Prototype of Lung Responses in Pneumonia

    • Jessica Humann, Kim LeMessurier, Elaine Tuomanen

    Pages 213-238

11. Staphylococcus aureus Infection in the Respiratory Tract

    • Alice Prince

    Pages 239-258

12. Pseudomonas aeruginosa and Mucosal Defenses in the Lung

    • Taylor S. Cohen

    Pages 259-269

13. Back Matter

    Pages 271-277

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In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens.  The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections.  It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae.   By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.

• Airway Pathogens
• Bacterial Pneumonia
• Gram-Negative Opportunists
• Mucosal Immunology
• infectious diseases

• Columbia University, New York, USA

  Alice Prince

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