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Adenosine

A Key Link between Metabolism and Brain Activity

Editors: Masino, Susan, Boison, Detlev (Eds.)

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  • For many years the “retaliatory metabolite” and neuromodulator adenosine has been recognized as an endogenous anticonvulsant and neuroprotective molecule
  • As the core molecule of ATP and of nucleic acids, adenosine forms a unique link between cell energy, gene regulation, and neuronal excitability
  • Emerging evidence ignites new hope for adenosine-based therapies in the central nervous system
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eBook 171,19 €
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  • ISBN 978-1-4614-3903-5
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Hardcover 239,19 €
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  • ISBN 978-1-4614-3902-8
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Softcover 213,81 €
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  • ISBN 978-1-4899-8755-6
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About this book

Homeostasis of key metabolites and metabolic health affects all bodily systems.  Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders.  Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions.  Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. 

Adenosine:  A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system.  Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism.  At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression.  Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function.  Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders.  This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Reviews

From the book reviews:

“This textbook catalogues the debate concerning adenosine metabolism and it’s possible role in ischemia, trauma, and epilepsy animal models. … I do recommend this book to cerebral ischemia researchers.” (Joseph J. Grenier, Amazon.com, August, 2014)


Table of contents (29 chapters)

Table of contents (29 chapters)

Buy this book

eBook 171,19 €
price for Spain (gross)
  • ISBN 978-1-4614-3903-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 239,19 €
price for Spain (gross)
  • ISBN 978-1-4614-3902-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 213,81 €
price for Spain (gross)
  • ISBN 978-1-4899-8755-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Adenosine
Book Subtitle
A Key Link between Metabolism and Brain Activity
Editors
  • Susan Masino
  • Detlev Boison
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-3903-5
DOI
10.1007/978-1-4614-3903-5
Hardcover ISBN
978-1-4614-3902-8
Softcover ISBN
978-1-4899-8755-6
Edition Number
1
Number of Pages
XVI, 680
Topics

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