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p53 in the Clinics

  • Book
  • © 2013

Overview

Editors:
  1. Pierre Hainaut

    1. International Prevention Research Instit, Lyon, France

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  2. Magali Olivier

    1. International Agency for Cancer Research, Lyon, France

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    You can also search for this editor in PubMed   Google Scholar

  3. Klas G. Wiman

    1. Cancer Center Karolinska (CCK), Dept. Oncology and Pathology, Karolinska Institute, Stockholm, Sweden

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    You can also search for this editor in PubMed   Google Scholar

  • Focuses on recent advances in translational research on p53

  • Explores the significance of the genetic diversity of p53

  • Discusses mutations as biomarkers in molecular pathology

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-x
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  2. TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer

    • Pierre Hainaut
    Pages 1-23

  3. The Inheritance of p53

    • Lukasz F. Grochola, Jorge Zeron-Medina, Emmanouela Repapi, Alexander E. Finlayson, Ying Cai, Gurinder Singh Atwal et al.
    Pages 25-46

  4. p53: Guardian of the Metabolome

    • Masha V. Poyurovsky, Carol Prives
    Pages 47-64

  5. The p53 Family and Stem Cell Biology

    • Massimiliano Agostini, Alessandro Rufini, Edward T. W. Bampton, Francesca Bernassola, Gerry Melino, Richard A. Knight
    Pages 65-76

  6. Mutant p53-Driven Tumorigenesis

    • Tamara Terzian, Guillermina Lozano
    Pages 77-93

  7. Humanised Mouse Models: Targeting the Murine p53 Locus with Human Sequences

    • Monica Hollstein, Yang Xu
    Pages 95-108

  8. p53 Models for Mammary Carcinogenesis

    • Wolfgang Deppert, Genrich Tolstonog
    Pages 109-126

  9. TP53 Somatic Mutations: Prognostic and Predictive Value in Human Cancers

    • Magali Olivier
    Pages 127-146

  10. Assessing TP53 Status in Human Tumors: Lessons from Breast Cancer

    • Anita Langerød, Magali Olivier, Anne-Lise Børresen-Dale
    Pages 147-165

  11. TP53 Germline Mutations: Genetics of Li–Fraumeni Syndrome

    • Doua Bakry, David Malkin
    Pages 167-188

  12. Tp53 Gene Therapy for Cancer Treatment and Prevention

    • Robert E. Sobol, Yong-Song Guan, Long-Jiang Li, Wei-Wei Zhang, Zhaohui Peng, Kerstin B. Menander et al.
    Pages 189-208

  13. Upstream Targets in the p53 Pathway

    • Anna R. McCarthy, Sonia Lain
    Pages 209-229

  14. p53-Reactivating Molecules as Research Tools and Anticancer Drugs

    • Vera V. Grinkevich, Andreas Warnecke, Galina Selivanova
    Pages 231-255

  15. Targeting Mutant p53 for Improved Cancer Therapy

    • Jinfeng Shen, Vladimir J. N. Bykov, Klas G. Wiman
    Pages 257-273

  16. p53 Immunotherapy of Cancer

    • Hakim Echchannaoui, Matthias Theobald
    Pages 275-287

  17. Designing p53 Trials: A Surgical Oncologists View

    • Daniela Kandioler, Sonja Kappel, Brigitte Wolf
    Pages 289-303

  18. p53 in the Clinic: A Pathologist’s View

    • Philippe Bertheau, Jean-François Fléjou, Yves Allory, Pascale Varlet, Sylvie Lantuejoul, Louis-François Plassa et al.
    Pages 305-326

  19. Genetic Counseling for TP53 Germline Mutations

    • Maria Isabel Waddington Achatz, Patricia Ashton-Prolla
    Pages 327-343

  20. Back Matter

    Pages 345-355
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Keywords

About this book

This project follows on the success of the book "25 years of p53", published by Springer in 2006. Since this publication, there have been considerable advances on the potential application of p53 into the clinics. The goal of this book is to capture these developments and to appeal to a clinical and medical audience beyond the one which was the primary target of "25 years of p53".

Editors and Affiliations

  • International Prevention Research Instit, Lyon, France

    Pierre Hainaut

  • International Agency for Cancer Research, Lyon, France

    Magali Olivier

  • Cancer Center Karolinska (CCK), Dept. Oncology and Pathology, Karolinska Institute, Stockholm, Sweden

    Klas G. Wiman

Bibliographic Information

  • Book Title: p53 in the Clinics

  • Editors: Pierre Hainaut, Magali Olivier, Klas G. Wiman

  • DOI: https://doi.org/10.1007/978-1-4614-3676-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-3675-1Published: 30 August 2012

  • Softcover ISBN: 978-1-4899-9217-8Published: 19 September 2014

  • eBook ISBN: 978-1-4614-3676-8Published: 30 August 2012

  • Edition Number: 1

  • Number of Pages: X, 358

  • Topics: Cancer Research, Pharmacology/Toxicology

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