Retinal Degenerative Diseases
Mechanisms and Experimental Therapy
Editors: Ash, J., Grimm, C., Hollyfield, J.G., Anderson, R.E., LaVail, M.M., Rickman, C.B. (Eds.)
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- A comprehensive source for the latest basic research in the field of retinal degenerative diseases
- Editorial Board comprises the most respected names in the field
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- About this book
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This book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012). A majority of those who will speak and present posters at the meeting will contribute to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field.
The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.
While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2010. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials.
The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2010 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.
- Table of contents (106 chapters)
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Cell Type-Specific Epigenetic Signatures Accompany Late Stages of Mouse Retina Development
Pages 3-8
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Programmed Cell Death During Retinal Development of the Mouse Eye
Pages 9-13
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Spatial and Temporal Localization of Caveolin-1 Protein in the Developing Retina
Pages 15-21
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Glutathione S-Transferase Pi Isoform (GSTP1) Expression in Murine Retina Increases with Developmental Maturity
Pages 23-30
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RETINA-Specific Expression of Kcnv2 Is Controlled by Cone-Rod Homeobox (Crx) and Neural Retina Leucine Zipper (Nrl)
Pages 31-41
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Table of contents (106 chapters)
- Download Preface 1 PDF (1.3 MB)
- Download Sample pages 1 PDF (1.6 MB)
- Download Table of contents PDF (1.5 MB)
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- Retinal Degenerative Diseases
- Book Subtitle
- Mechanisms and Experimental Therapy
- Editors
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- John Ash
- Christian Grimm
- Joe G. Hollyfield
- Robert E. Anderson
- Matthew M LaVail
- Catherine Bowes Rickman
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- 801
- Copyright
- 2014
- Publisher
- Springer-Verlag New York
- Copyright Holder
- Springer Science+Business Media, LLC, part of Springer Nature
- eBook ISBN
- 978-1-4614-3209-8
- DOI
- 10.1007/978-1-4614-3209-8
- Hardcover ISBN
- 978-1-4614-3208-1
- Softcover ISBN
- 978-1-4939-5276-2
- Series ISSN
- 0065-2598
- Edition Number
- 1
- Number of Pages
- LXI, 862
- Number of Illustrations
- 1 b/w illustrations, 187 illustrations in colour
- Topics
