Medical Intelligence Unit
cover

Molecular Pathogenesis of Cholestasis

Editors: Trauner, Michael, Jansen, Peter L. M. (Eds.)

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About this book

membrane contamination and thus could then be used to study transport function when pre­ pared as membrane vesicles. These approaches defined a number of transport functions in the plasma membranes of hepatocyres and ultimately led to the recognition that bile salts and 3 25 other solutes were transported into bile largely by ATP dependent transport mechanisms.2 - The advent ofmolecular cloning techniques and cellular expression systems rapidly acceler­ ated progress in this field and led to the molecular characterization ofmost ofthe major mem­ brane transport proteins that determine both the hepatic uptake of organic solutes as well as bile salt dependent and bile salt independent canalicular excretion. Overview of the Molecular Mechanisms of Bile Formation The major transporters that determine bile formation are illustrated in Figure 1 and are discussed in greater detail in the subsequent chapters. The enrerohepatic circulation ofbile salts maintains bile salt dependent bile flow. Bile salts are excreted into bile and are largely absorbed in the terminal ileum and then efficiently removed from the portal circulation at the basolateral plasma membrane of the heparocyte. Each of these steps is dependent on the function of bile salt transport proteins.

Buy this book

Softcover 67,59 €
price for Spain (gross)
  • ISBN 978-1-4613-4767-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Pathogenesis of Cholestasis
Editors
  • Michael Trauner
  • Peter L. M. Jansen
Series Title
Medical Intelligence Unit
Copyright
2004
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
Softcover ISBN
978-1-4613-4767-5
Edition Number
1
Number of Pages
XIII, 366
Topics