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- About this book
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A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-
- Table of contents (22 chapters)
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A Model for Cell-Line Divergence in the Ontogeny of the Peripheral Nervous System
Pages 3-28
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Emergence of Neuronal and Glial Cell Lineages in Primate Brain
Pages 29-50
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Heterogeneity in Neural Crest Cell Populations
Pages 51-62
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The First Growth Cones in the Central Nervous System of the Grasshopper Embryo
Pages 63-84
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Surface-Bound and Released Neuronal Glycoconjugates
Pages 87-94
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Table of contents (22 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Cellular and Molecular Biology of Neuronal Development
- Authors
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- Ira Black
- Copyright
- 1984
- Publisher
- Springer US
- Copyright Holder
- Plenum Press, New York
- eBook ISBN
- 978-1-4613-2717-2
- DOI
- 10.1007/978-1-4613-2717-2
- Softcover ISBN
- 978-1-4612-9686-7
- Edition Number
- 1
- Number of Pages
- XXVI, 363
- Number of Illustrations
- 148 b/w illustrations
- Topics
