Developmental Biology

Manipulation of Mammalian Development

Editors: Gwatkin, Ralph B.L. (Ed.)

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About this book

Developmental biology has been transformed recently by discoveries in the fields of molecular biology, cell biology, and immunology. New ways of manip­ ulating mammalian development are uncovering control mechanisms and ena­ bling us to apply them in solving practical problems in animal production and human health. This book outlines some of these new manipulations and how they have contributed to the present state of developmental biology. Chapter 1 describes gene transfer by micro injection of cloned recombinant DNA into zygotes. Although the factors that affect transformation frequencies and integration sites are still unknown, such techniques offer a number of exciting prospects. Research models for human disease coula be artificially created and desirable characteristics in agricultural animals could be - hanced. . The theme of cell-to-cell transfer is continued in Chapters 2 and 3. Chapter 2 describes pronuclear transplantation by Sendai virus-induced fusion of the karyoplast with the enucleated embryo. Using this procedure, it has been dem­ onstrated that both male and female genomes are essential for normal develop­ ment, although the reason for this is not yet understood. Chapter 3 describes studies on the fusion of whole oocytes. .

Table of contents (13 chapters)

Table of contents (13 chapters)

Buy this book

eBook 96,29 €
price for Spain (gross)
  • ISBN 978-1-4613-2143-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Softcover 124,79 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Manipulation of Mammalian Development
Editors
  • Ralph B.L. Gwatkin
Series Title
Developmental Biology
Series Volume
4
Copyright
1986
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4613-2143-9
DOI
10.1007/978-1-4613-2143-9
Softcover ISBN
978-1-4612-9265-4
Edition Number
1
Number of Pages
XIV, 402
Number of Illustrations
62 b/w illustrations
Topics