Developments in Cardiovascular Medicine

Myocardial Ischemia

Proceedings of a Satellite Symposium of the Thirtieth International Physiological Congress July 8–11, 1986, Winnipeg, Canada

Editors: Dhalla, Naranjan S, Innes, Ian R., Beamish, Robert E. (Eds.)

Free Preview

Buy this book

eBook 71,68 €
price for Spain (gross)
  • ISBN 978-1-4613-2055-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 90,47 €
price for Spain (gross)
  • ISBN 978-1-4612-9221-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

Whenever the coronary flow is inadequate to provide enough oxygen to meet the energy demands of the tissue, the heart becomes ischemic. Manifestations of myocardial ischemia include depression in contractile activity, changes in metabolic pattern, abnormalities in ultrastructure, and alterations in membrane potential. Ischemic changes during the early phase are reversible but as the period of ischemia is extended, the injury becomes irreversible. The transition from reversible to irreversible ischemic injury is usually associated with some membrane defects. It is worthwhile to consider that the irreversible damage to the ischemic myocardium occurs when the sarcolemmal membrane is altered in suoh a way that it would promote 2 a net gain of ca + in the cardiac cell upon reinstitution of blood flow. Suoh a lesion could result when mechanisms for the entry as well as removal 2 of ca + from the myocardial oell become defective. In this regard, 2 depression of the sarcolemmal ca + pump would favour the oocurrenoe of 2 intracellular ca + overload. Furthermore, inhibition of the Na+-K+ pump would lead to elevation of myoplasmic Na+ which oould then increase the 2 2 intracellular concentration of ca + through the sarcolemmal Na+-ca + exchange mechanism. In faot recent studies have revealed an inhibition of 2 the sarcolemmal Na+-ca + exchange mechanism in the ischemic heart and this 2 change could also contribute towards the occurrence of intracellular ca + 2 overload.

Table of contents (28 chapters)

Table of contents (28 chapters)
  • Ultrastructural Abnormalities in Ischemic Heart Disease

    Pages 3-9

    Schaper, Jutta

  • Preconditioning with Ischemia: A Means to Delay Cell Death in Ischemic Myocardium

    Pages 11-20

    Murry, Charles E. (et al.)

  • Modification of the Thromboxane/Prostacyclin Balance as an Approach to Antiarrhythmic Therapy During Myocardial Ischaemia and Reperfusion; The Concept of Endogenous Antiarrhythmic Substances

    Pages 21-35

    Parratt, James R.

  • Mechanisms of Coupled Arrhythmias in Guinea Pig Perfused Heart and Isolated Ventricular Tissue Models of Ischemia-Reperfusion

    Pages 37-51

    Ferrier, Gregory R. (et al.)

  • The Preventive Effect of Sodium Selenite Against Ischemic Ventricular Arrhythmia and Some Clues to its Mechanisms

    Pages 53-63

    Mei, Y. A. (et al.)

Buy this book

eBook 71,68 €
price for Spain (gross)
  • ISBN 978-1-4613-2055-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 90,47 €
price for Spain (gross)
  • ISBN 978-1-4612-9221-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
Loading...

Bibliographic Information

Bibliographic Information
Book Title
Myocardial Ischemia
Book Subtitle
Proceedings of a Satellite Symposium of the Thirtieth International Physiological Congress July 8–11, 1986, Winnipeg, Canada
Editors
  • Naranjan S Dhalla
  • Ian R. Innes
  • Robert E. Beamish
Series Title
Developments in Cardiovascular Medicine
Series Volume
67
Copyright
1987
Publisher
Springer US
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-1-4613-2055-5
DOI
10.1007/978-1-4613-2055-5
Softcover ISBN
978-1-4612-9221-0
Series ISSN
0166-9842
Edition Number
1
Number of Pages
XIV, 353
Number of Illustrations
48 b/w illustrations
Topics