Phenotypes and Genotypes
The Search for Influential Genes
Authors: Frommlet, Florian, Bogdan, Małgorzata, Ramsey, David
Free Preview- Introduces the major concepts of Quantitative Trait Loci mapping
- Discusses the methodology of Quantitative Trait Loci mapping in experimental populations
- Describes the methods for Genome Wide Association Studies and related multiple testing and model selection problems
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- About this book
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This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.
- About the authors
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Dr. Florian Frommlet is a researcher in the Center for Medical Statistics, Informatics, and Intelligent Systems at the Medical University of Vienna, Austria.
Dr. Małgorzata Bogdan is an Associate Professor in the Institute of Mathematics at Wrocław University, Poland.
Dr. David Ramsey is a Senior Lecturer in the Department of Operations Research at Wrocław University of Technology, Poland.
- Table of contents (10 chapters)
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Introduction
Pages 1-8
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A Primer in Genetics
Pages 9-30
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Statistical Methods in High Dimensions
Pages 31-72
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Statistical Methods of QTL Mapping for Experimental Populations
Pages 73-104
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Statistical Analysis of GWAS
Pages 105-161
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Table of contents (10 chapters)
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- Phenotypes and Genotypes
- Book Subtitle
- The Search for Influential Genes
- Authors
-
- Florian Frommlet
- Małgorzata Bogdan
- David Ramsey
- Series Title
- Computational Biology
- Series Volume
- 18
- Copyright
- 2016
- Publisher
- Springer-Verlag London
- Copyright Holder
- Springer-Verlag London
- eBook ISBN
- 978-1-4471-5310-8
- DOI
- 10.1007/978-1-4471-5310-8
- Hardcover ISBN
- 978-1-4471-5309-2
- Softcover ISBN
- 978-1-4471-7380-9
- Series ISSN
- 1568-2684
- Edition Number
- 1
- Number of Pages
- XII, 222
- Number of Illustrations
- 13 b/w illustrations, 20 illustrations in colour
- Topics
