Epigenetic Contributions in Autoimmune Disease
Editors: Ballestar, Esteban (Ed.)
Free Preview- Overview of some of the key concepts in epigenetics, chromatin and the interaction with transcription factors
- Shows the specific influence of environmental factors to influence or trigger the autoimmune response
- Discusses the possibilities of using epigenetics-based therapies in the context of autoimmune diseases
- Presents the application of novel methods to characterize the epigenetic profile
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- About this book
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This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.
- About the authors
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ESTEBAN BALESTAR is head of the Chromatin and Disease Group at the Cancer Epigenetics and Biology Programme (PEBC) of the Bellvitge Biomedical Research Institute (IDIBELL ) in Barcelona, Spain. Ballestar obtained his PhD degree from the University of Valencia under the supervision of Prof. Luis Franco, specialising in chromatin and histone modifications (1997). He then worked as a Postdoctoral Fellow at the National Institutes of Health, (Bethesda, MD, USA) in the laboratory of Dr. Alan Wolffe where he investigated associations between elements of the chromatin machinery and methylated DNA. From 2001 to 2008, Esteban Ballestar has worked at the CNIO Cancer Epigenetics Laboratory, in association with Dr. Manel Esteller, where his principal area of research has been the study of the implication of chromatin factors in epigenetic alterations in human cancer. His current research is devoted to the establishment of different mechanisms of epigenetic deregulation in the context of the hematopoietic system in both autoimmune diseases and hematological malignancies.
- Table of contents (12 chapters)
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An Introduction to Epigenetics
Pages 1-11
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Chromatin Mechanisms Regulating Gene Expression in Health and Disease
Pages 12-25
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Epigenetic Control of Lymphocyte Differentiation
Pages 26-35
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Epigenetic Control in Immune Function
Pages 36-49
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DNA Methylation and B-Cell Autoreactivity
Pages 50-60
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Table of contents (12 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Epigenetic Contributions in Autoimmune Disease
- Editors
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- Esteban Ballestar
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- 711
- Copyright
- 2011
- Publisher
- Springer US
- Copyright Holder
- Landes Bioscience and Springer Science+Business Media, LLC
- eBook ISBN
- 978-1-4419-8216-2
- DOI
- 10.1007/978-1-4419-8216-2
- Hardcover ISBN
- 978-1-4419-8215-5
- Series ISSN
- 0065-2598
- Edition Number
- 1
- Number of Pages
- XVI, 182
- Topics
