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Principles of Anticancer Drug Development

  • Book
  • © 2011

Overview

Editors:
  1. Elizabeth Garrett-Mayer

    1. Dept. Biostatistics, Bioinformatics &, Epidemiology, Medical University of South Carolina, Charleston, USA

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  • This book takes a look at: Basic Biostatistics for the Clinical Trialist, Fundamental Concepts in Clinical Pharmacology, Analytical Methods in Drug Development, and Preclinical Efficacy Evaluation of Anticancer Agents.
  • It is a practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.
  • Additionally, Clinical Trials with Anticancer Agents are reviewed, and many other topics in the area of anticancer drug development.
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Part I

    1. Front Matter

      Pages 1-1
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    2. Basic Biostatistics for the Clinical Trialist

      • Elizabeth G. Hill, Elizabeth Garrett-Mayer
      Pages 3-35

    3. Fundamental Concepts in Clinical Pharmacology

      • Daniel L. Gustafson, Erica L. Bradshaw-Pierce
      Pages 37-62

    4. Bioanalytical Methods in Clinical Drug Development

      • Walter J. Loos, Peter de Bruijn, Alex Sparreboom
      Pages 63-86

  3. Part II

    1. Front Matter

      Pages 87-87
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    2. Preclinical Models for Anticancer Drug Development

      • Edward A. Sausville
      Pages 89-114

  4. Part III

    1. Front Matter

      Pages 115-115
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    2. Phase I Clinical Trials with Anticancer Agents

      • Stephen Leong, Justin Call, Alex A. Adjei, Wells Messersmith
      Pages 117-139

    3. Phase II Trials with Anticancer Agents

      • Hui K. Gan, J. Jack Lee, Lillian L. Siu
      Pages 141-161

    4. Phase III Clinical Trials with Anticancer Agents

      • Wendy R. Parulekar, Daniel J. Sargent
      Pages 163-188

    5. Pharmacokinetic Studies in Early Anticancer Drug Development

      • Alex Sparreboom, Sharyn D. Baker
      Pages 189-214

    6. Pharmacodynamic Studies in Early Phase Drug Development

      • D. Ross Camidge, Robert C. Doebele, Antonio Jimeno
      Pages 215-256

    7. Prediction of Antitumor Response

      • Fred R. Hirsch, Yu Shyr
      Pages 257-274

    8. Imaging Studies in Anticancer Drug Development

      • David A. Mankoff
      Pages 275-302

  5. Part IV

    1. Front Matter

      Pages 303-303
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    2. Role of the US Food and Drug Administration in Cancer Drug Development

      • Ann T. Farrell, Ramzi N. Dagher, Richard Pazdur
      Pages 305-332

  6. Part V

    1. Front Matter

      Pages 333-333
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    2. Early Clinical Trials with Cytotoxic Agents

      • M. J. A. de Jonge, Jaap Verweij
      Pages 335-345

    3. Challenges and Successes in Developing Effective Anti-angiogenic Agents

      • Laura Q. M. Chow, S. Gail Eckhardt
      Pages 347-401
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Keywords

About this book

A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Editors and Affiliations

  • Dept. Biostatistics, Bioinformatics &, Epidemiology, Medical University of South Carolina, Charleston, USA

    Elizabeth Garrett-Mayer

Bibliographic Information

  • Book Title: Principles of Anticancer Drug Development

  • Editors: Elizabeth Garrett-Mayer

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-4419-7358-0

  • Publisher: Humana New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Busines Media, LLC 2011

  • Hardcover ISBN: 978-1-4419-7357-3Published: 30 December 2010

  • Softcover ISBN: 978-1-4614-2791-9Published: 28 January 2013

  • eBook ISBN: 978-1-4419-7358-0Published: 29 December 2010

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XVIII, 674

  • Topics: Cancer Research

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