Inflammation and Retinal Disease: Complement Biology and Pathology

1. Front Matter

   Pages i-xiii

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2. The Case for Complement and Inflammation in AMD: Open Questions

   • Natalia Karagianni, Anthony P. Adamis

   Pages 1-7

3. The Role of Complement in AMD

   • Peter F. Zipfel, Nadine Lauer, Christine Skerka

   Pages 9-24

4. Multiple Interactions of Complement Factor H with Its Ligands in Solution: A Progress Report

   • Stephen J. Perkins, Ruodan Nan, Azubuike I. Okemefuna, Keying Li, Sanaullah Khan, Ami Miller

   Pages 25-47

5. Genetic Control of Complement Activation in Humans and Age Related Macular Degeneration

   • Laura A. Hecker, Albert O. Edwards

   Pages 49-62

6. Bisretinoids of RPE Lipofuscin: Trigger for Complement Activation in Age-Related Macular Degeneration

   • Janet R. Sparrow

   Pages 63-74

7. The Role of the Classical Complement Cascade in Synapse Loss During Development and Glaucoma

   • Allison M. Rosen, Beth Stevens

   Pages 75-93

8. A Role for Complement in Glaucoma?

   • Lizhen Ren, John Danias

   Pages 95-104

9. The ATP-Binding Cassette Transporter ABCA4: Structural and Functional Properties and Role in Retinal Disease

   • Yaroslav Tsybovsky, Robert S. Molday, Krzysztof Palczewski

   Pages 105-125

10. Suppression of Drusen Formation by Compstatin, a Peptide Inhibitor of Complement C3 activation, on Cynomolgus Monkey with Early-Onset Macular Degeneration

    • Zai-Long Chi, Tsunehiko Yoshida, John D. Lambris, Takeshi Iwata

    Pages 127-135

11. A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-Related Macular Degeneration

    • Bärbel Rohrer, Qin Long, Beth Coughlin, Brandon Renner, Yuxiang Huang, Kannan Kunchithapautham et al.

    Pages 137-149

12. Complement Depletion with Humanized Cobra Venom Factor in a Mouse Model of Age-Related Macular Degeneration

    • David C. Fritzinger, Robin Dean, Carol Meschter, Katina Wong, Roman Halter, Jürgen Borlak et al.

    Pages 151-162

13. Back Matter

    Pages 163-167

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Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical candidates covering a wide area of potential treatment applications are in the pipelines of both industrial and academic groups. This indicates an increasing interest in complement as a therapeutic target. In view of these exciting discoveries, scientists from around the world convened at the First Aegean Conferences Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (June 10–17, 2007) in Crete, Greece, to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the functions of complement in eye diseases, pathophysiology, protein structures, and complement therapeutics discussed during the conference. Our sincere thanks to the contributing authors for the time and effort they have devoted to writing what I consider exceptionally informative chapters in a book that will have a significant impact on the complement field. We would also like to express my thanks to Rodanthi Lambris for her assistance in collating the chapters and preparing the documents for publication and I gratefully acknowledge the generous help provided by Dimitrios Lambris in managing the organization of this meeting. Finally, I also thank Andrea Macaluso of Springer Publishers for her supervision in this book’s production. John D. Lambris Anthony P.

• eye
• macular degeneration
• pathogenesis
• pathology
• retina

• Department Of Pathology Laboratory Of, Medicine, University Of Pennsylvania, Philadelphia, USA

  John D. Lambris

• , Department of Ophthalmology and Visual S, University of Illinois at Chicago, Chicago, USA

  Anthony P. Adamis

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