Handbook on Immunosenescence
basic understanding and clinical applications
Editors: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (Eds.)
Free Preview- Comprehensive: covers all aspects of immunosenescence in one volume
- Offers a bridge in the field between research and clinical applications
- Useful for anti-aging research and clinical practice
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- About this book
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“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”
- Reviews
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From the reviews: “The Handbook on Immunosenescence, a 1,650-page 2-volume encyclopedia on aging research with 78 articles, includes 5 sections … . Its strength is the broad coverage of aging, the immune system, and diseases of the elderly. For this reason, the Handbook on Immunosenescence is a worthy addition to any medical library.” (Marc E. Weksler, Gerontology, Vol. 56 (3), March, 2010)
- Table of contents (77 chapters)
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The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies
Pages 3-28
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Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing
Pages 29-62
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Mouse Models and Genetics of Immunosenescence
Pages 63-85
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Insect Models of Immunosenescence
Pages 87-105
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Clonal Culture Models of T-cell Senescence
Pages 107-115
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Table of contents (77 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Handbook on Immunosenescence
- Book Subtitle
- basic understanding and clinical applications
- Editors
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- Tamas Fulop
- Claudio Franceschi
- Katsuiki Hirokawa
- Graham Pawelec
- Copyright
- 2009
- Publisher
- Springer Netherlands
- Copyright Holder
- Springer Science+Business Media B.V.
- eBook ISBN
- 978-1-4020-9063-9
- DOI
- 10.1007/978-1-4020-9063-9
- Hardcover ISBN
- 978-1-4020-9062-2
- Softcover ISBN
- 978-94-017-7721-6
- Edition Number
- 1
- Number of Pages
- XXXI, 1693
- Topics
