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Structure-based Drug Discovery

Editors: Jhoti, Harren, Leach, Andrew R. (Eds.)

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eBook 117,69 €
price for Spain (gross)
  • ISBN 978-1-4020-4407-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover 155,99 €
price for Spain (gross)
Softcover 145,78 €
price for Spain (gross)
About this book

Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.

Structure-based drug discovery describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being used worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.

This book is an invaluable resource for medicinal chemists in industry, computational chemists, drug discovery scientists and postgraduates in chemistry or structural biology.

Reviews

From the reviews:

"Structure-based drug design (SBDD) is now an integral component of the drug discovery process. … The book’s core subject matter of fragment-based screening is an exciting and important development in drug discovery. These chapters are generally the strongest in the book and make it a good reference volume … ." (Robert Powers, Journal of the American Chemical Society, Vol. 129 (32), 2007)


Table of contents (9 chapters)

Table of contents (9 chapters)
  • Five Years of Increasing Structural Biology Throughput - A Retrospective Analysis

    Pages 1-26

    Abola, Enrique (et al.)

  • Protein Production for Structural Genomics - Strategies for the Next Phase

    Pages 27-48

    Nordlund, Pär (et al.)

  • Introduction to Fragment Screening

    Pages 49-72

    Leach, Andrew R. (et al.)

  • Fragment-Based NMR Screening in Lead Discovery

    Pages 72-98

    Lepre, Christopher A. (et al.)

  • Fragment-Based Screening by X-ray Crystallography

    Pages 99-127

    Berdini, Valerio (et al.)

Buy this book

eBook 117,69 €
price for Spain (gross)
  • ISBN 978-1-4020-4407-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover 155,99 €
price for Spain (gross)
Softcover 145,78 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Structure-based Drug Discovery
Editors
  • Harren Jhoti
  • Andrew R. Leach
Copyright
2007
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-4407-6
DOI
10.1007/1-4020-4407-0
Hardcover ISBN
978-1-4020-4406-9
Softcover ISBN
978-90-481-7123-1
Edition Number
1
Number of Pages
XII, 250
Topics