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Bioassays in Experimental and Preclinical Pharmacology

  • Book
  • © 2021

Overview

Authors:
  1. Karuppusamy Arunachalam

    1. Kunming Institute of Botany, Chinese Academy of Sciences, Department of Basic Sciences in Health, Federal University of Mato Grosso (UFMT), Cuiabá, MT, Brazil, Kunming, China

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  2. Sreeja Puthanpura Sasidharan

    1. C/o Sreeja-P.S. “Sruthilayam”, Kamba, Kinavallur Post Office, Parli, India

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  • Includes detailed protocols that are lab-ready
  • Features advice from the authors on how best to implement the well-honed techniques
  • Contains both in vitro and in vivo protocols for full coverage of the preclinical process

Part of the book series: Springer Protocols Handbooks (SPH)

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Table of contents (24 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Overview

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 1-2

  3. Cell Culture Assays

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 3-19

  4. Phytochemical Analysis

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 21-28

  5. Preclinical Drug Dose Calculation

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 29-32

  6. Toxicology Studies: In Vitro and In Vivo

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 33-44

  7. Standard Procedure for Anaesthesia in Preclinical Experiments

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 45-49

  8. General Considerations and Collection of Animal Blood

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 51-55

  9. Animal Experiments on the Cardiovascular System

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 57-62

  10. Animal Experiments on Ulcerative Colitis

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 63-73

  11. Experiments of Antibacterial Activities

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 75-90

  12. Experiments of Antifungal Activities

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 91-103

  13. Animal Experiment of Wound Healing Activity

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 105-118

  14. Animal Experiments of Anti-inflammatory Activities

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 119-136

  15. Animal Experiment of Anti-nociceptive Activities

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 137-142

  16. Experiments of Antioxidant Activities

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 143-155

  17. Animal Experiments of Hepatoprotective Activities

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 157-166

  18. Animal Experiments of Anti-Diarrhoeal Activities

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 167-172

  19. Animal Experiments of Central Nervous System (CNS)

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 173-180

  20. Experiments of Anti-Cancer Activities (In Vitro and In Vivo)

    • Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan
    Pages 181-190
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Keywords

About this book

This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. 

Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.

Authors and Affiliations

  • Kunming Institute of Botany, Chinese Academy of Sciences, Department of Basic Sciences in Health, Federal University of Mato Grosso (UFMT), Cuiabá, MT, Brazil, Kunming, China

    Karuppusamy Arunachalam

  • C/o Sreeja-P.S. “Sruthilayam”, Kamba, Kinavallur Post Office, Parli, India

    Sreeja Puthanpura Sasidharan

Bibliographic Information

  • Book Title: Bioassays in Experimental and Preclinical Pharmacology

  • Authors: Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan

  • Series Title: Springer Protocols Handbooks

  • DOI: https://doi.org/10.1007/978-1-0716-1233-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1232-3Published: 17 February 2021

  • Softcover ISBN: 978-1-0716-1235-4Published: 17 February 2022

  • eBook ISBN: 978-1-0716-1233-0Published: 16 February 2021

  • Series ISSN: 1949-2448

  • Series E-ISSN: 1949-2456

  • Edition Number: 1

  • Number of Pages: XII, 271

  • Number of Illustrations: 4 b/w illustrations

  • Topics: Pharmacology/Toxicology, Biomedicine, general, Drug Safety and Pharmacovigilance

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