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Translational Methods for Multiple Sclerosis Research

  • Book
  • © 2021

Overview

Editors:
  1. Sergiu Groppa

    1. Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Sven G. Meuth

    1. Department of Neurology, University of Düsseldorf, Düsseldorf, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Neuromethods (NM, volume 166)

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Table of contents (21 protocols)

  1. Front Matter

    Pages i-xi
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  2. Pathophysiological Fingerprints of MS and Related Neuroimmunological Disorders

    1. Front Matter

      Pages 1-1
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    2. Pathophysiological Bases of Autoimmune-Initiated/Mediated Neurodegeneration

      • Hans Lassmann
      Pages 3-12

    3. Translational Animal Models for MS and Related Neuroimmunological Disorders

      • Felix M. Glaser, Tobias Ruck
      Pages 13-27

    4. White Matter Pathology

      • Angela Radetz, Sergiu Groppa
      Pages 29-46

    5. Pathophysiology of Grey Matter Affection in MS

      • Gabriel Gonzalez-Escamilla, Dumitru Ciolac
      Pages 47-60

    6. Translational Characterization of the Glia Role in Multiple Sclerosis

      • Dumitru Ciolac, Stanislav A. Groppa, Gabriel Gonzalez-Escamilla
      Pages 61-76

    7. Translational Value of CSF and Blood Markers of Autoimmunity and Neurodegeneration

      • Timo Uphaus, Stefan Bittner
      Pages 77-86

  3. Animal Models of Neuroinflammation

    1. Front Matter

      Pages 87-87
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    2. Spontaneous Mouse Models of Neuroinflammation

      • Shin-Young Na, Gurumoorthy Krishnamoorthy
      Pages 89-107

    3. Chronic Progressive Models

      • Maren Lindner, Ann-Katrin Fleck, Luisa Klotz
      Pages 109-120

    4. Electrophysiological Measurements for Brain Network Characterization in Rodents

      • Manuela Cerina, Luca Fazio, Sven G. Meuth
      Pages 121-135

  4. Translation of Functional Domain Abnormalities from Human to Mice

    1. Front Matter

      Pages 137-137
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    2. Translation of Functional Domain Abnormalities from Human to Mouse Motor System

      • Muthuraman Muthuraman, Dumitru Ciolac, Venkata Chaitanya Chirumamilla
      Pages 139-152

    3. Characterization of the Somatosensory System

      • Carsten H. Wolters, Marios Antonakakis, Asad Khan, Maria Carla Piastra, Johannes Vorwerk
      Pages 153-169

    4. Translational Research in Neuroimmunology: Cognition

      • Maren Person, Miriam Becke
      Pages 171-182

    5. Models for Assessing Anxiety and Depression in Multiple Sclerosis: from Mouse to Man

      • Erik Ellwardt, Dirk Luchtman
      Pages 183-195

  5. Exploring Translational Paths in MS with Brain Imaging: Small Animal to Human Imaging Tools

    1. Front Matter

      Pages 197-197
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    2. Human Structural MRI

      • Menno M. Schoonheim
      Pages 199-211

    3. Human Functional MRI

      • Paolo Preziosa, Paola Valsasina, Massimo Filippi, Maria A. Rocca
      Pages 213-236
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Keywords

About this book

This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. 

Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements. 



Editors and Affiliations

  • Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany

    Sergiu Groppa

  • Department of Neurology, University of Düsseldorf, Düsseldorf, Germany

    Sven G. Meuth

Bibliographic Information

  • Book Title: Translational Methods for Multiple Sclerosis Research

  • Editors: Sergiu Groppa, Sven G. Meuth

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-0716-1213-2

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1212-5Published: 24 May 2021

  • Softcover ISBN: 978-1-0716-1215-6Published: 23 May 2021

  • eBook ISBN: 978-1-0716-1213-2Published: 23 May 2021

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XI, 333

  • Number of Illustrations: 2 b/w illustrations, 27 illustrations in colour

  • Topics: Neurosciences

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