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  • © 2021

Metabotropic Glutamate Receptor Technologies

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Neuromethods (NM, volume 164)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-xii
  2. Technologies for Screening of mGlu Receptor Allosteric Modulators

    • Alice L. Rodriguez, Colleen M. Niswender
    Pages 1-22
  3. Positron Emission Tomography (PET) Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Based on a Negative Allosteric Modulator Radioligand

    • Xiaofei Zhang, Zhiwei Xiao, Katsushi Kumata, Tomoteru Yamasaki, Lee Josephson, Ming-Rong Zhang et al.
    Pages 23-37
  4. PET Imaging of Type 5 Metabotropic Glutamate Receptors

    • Stephanie G. Scala, Kelly Smart, Sylvia M. L. Cox, Chawki Benkelfat, Marco Leyton
    Pages 39-56
  5. Role of Metabotropic Glutamate Receptors (mGluRs) in the Regulation of Cellular Calcium Signaling: Theory, Protocols, and Data Analysis

    • Vaibhav Dhyani, Sarpras Swain, Rishikesh Kumar Gupta, Abha Saxena, Ranjana Singh, Lopamudra Giri
    Pages 81-115
  6. Optical Approaches for Modulating mGlu Receptor Activity

    • Lauren E. Hood, Jonna M. Leyrer-Jackson, M. Foster Olive
    Pages 117-133
  7. Fluorescence Immunohistochemistry Techniques for Labeling Metabotropic Glutamate Receptors in the Central Nervous System

    • Ryan S. Pevey, Jonna M. Leyrer-Jackson, Erin Nagy, M. Foster Olive
    Pages 227-242
  8. Role of Metabotropic Glutamate Receptors in Alcohol-Drinking Behaviors

    • Fawaz Alasmari, Musaad A. Alshammari, Youssef Sari
    Pages 297-311
  9. Back Matter

    Pages 313-314

About this book

This volume highlights various techniques used to study multiple aspects of mGlu receptor function. Chapters in this book cover topics such as modern approaches for the development and screening of allosteric modulators; fluctuations in intracellular calcium induced by mGlu receptor activation; dopamine-glutamate interactions in the central nervous system; methods for assessing mGlu receptor localization; and common techniques for evaluating mGlu modulation in behavior in rodents, including stress and alcohol drinking. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.


Cutting-edge and practical, Metabotropic Glutamate Receptor Technologies provides researchers with a starting point to address important questions regarding mGlu and its importance. Researchers working in the fields of neuroscience and physiology of multiple peripheral systems will find this volume most useful. 


Editors and Affiliations

  • Psychology Department, Arizona State University, Tempe, USA

    M Foster Olive, Jonna M. Leyrer-Jackson

  • Phoenix Children’s Hospital, Barrow Neurological Institute, Phoenix, USA

    Brian T. Burrows

Bibliographic Information

  • Book Title: Metabotropic Glutamate Receptor Technologies

  • Editors: M Foster Olive, Brian T. Burrows, Jonna M. Leyrer-Jackson

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-0716-1107-4

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1106-7Published: 12 February 2021

  • Softcover ISBN: 978-1-0716-1109-8Published: 12 February 2022

  • eBook ISBN: 978-1-0716-1107-4Published: 11 February 2021

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XII, 314

  • Number of Illustrations: 11 b/w illustrations, 60 illustrations in colour

  • Topics: Neurosciences

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access