Nanomedicines for Brain Drug Delivery

1. Front Matter

   Pages i-xii

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2. Biodegradable Polymeric Nanoparticles for Brain-Targeted Drug Delivery

   • Kristian Kempe, Joseph A. Nicolazzo

   Pages 1-27

3. Liposomes as Brain Targeted Delivery Systems

   • Francesco Lai, Michele Schlich, Chiara Sinico, Anna Maria Fadda

   Pages 29-59

4. Nanofibers and Nanostructured Scaffolds for Nervous System Lesions

   • Jose L. Gerardo Nava, Jonas C. Rose, Haktan Altinova, Paul D. Dalton, Laura De Laporte, Gary A. Brook

   Pages 61-101

5. Self-Assembling Peptide Nanofibrous Scaffolds in Central Nervous System Lesions

   • Na Zhang, Liumin He, Wutian Wu

   Pages 103-117

6. The Use of Peptide and Protein Vectors to Cross the Blood-Brain Barrier for the Delivery of Therapeutic Concentration of Biologics

   • Mei Mei Tian, Reinhard Gabathuler

   Pages 119-147

7. Inorganic Nanoparticles and Their Strategies to Enhance Brain Drug Delivery

   • Eduardo Gallardo-Toledo, Carolina Velasco-Aguirre, Marcelo Javier Kogan

   Pages 149-172

8. Magnetic Nanoparticles as Delivery Systems to Penetrate the Blood-Brain Barrier

   • Joan Estelrich, Maria Antònia Busquets

   Pages 173-208

9. Nose-to-Brain Drug Delivery Enabled by Nanocarriers

   • Zachary Warnken, Yang Lu, Hugh D. C. Smyth, Robert O. Williams III

   Pages 209-233

10. In Vitro Models of Central Nervous System Barriers for Blood-Brain Barrier Permeation Studies

    • Sounak Bagchi, Behnaz Lahooti, Tanya Chhibber, Sree-pooja Varahachalam, Rahul Mittal, Abhijeet Joshi et al.

    Pages 235-253

11. Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery

    • Johanna Catalan-Figueroa, Javier O. Morales

    Pages 255-277

12. Back Matter

    Pages 279-280

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This volume explores the latest research in central nervous system (CNS) targeted nanocarriers, methods for their synthesis, and its characterization process. Chapters in this book cover topics such as polymeric nanoparticles and liposomes; self-assembled peptide-based scaffolds for lesions of the nervous system; use of peptides as CNS drugs and as potential carriers to optimize brain-targeted delivery; ways to model and assess blood brain barrier absorption of drugs; and the role of neurodegeneration progress of nanomaterials and their potential toxicity concerns. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.


Thorough and cutting-edge, Nanomedicines for Brain Drug Delivery is a valuable resource that will help researchers guide and advance the field of nanomedicines for the brain and nervous system.

• Polymeric nanoparticles
• Magnetic nanoparticles
• CNS drug exposure
• BBB permeation
• Nanocarriers
• Blood brain barrier

• Department of Pharmaceutical Science and Technology, University of Chile, Santiago, Chile

  Javier O. Morales

• 2-BBB Medicines BV, Leiden, The Netherlands

  Pieter J. Gaillard

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