Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy

1. Front Matter

   Pages i-xii

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2. Concepts

   1. Front Matter

      Pages 1-1

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   2. DNA filter elution methods in anticancer drug development

      • Kurt W. Kohn

      Pages 3-38

   3. Intraperitoneal chemotherapy: Principles and results of clinical trials

      • Maurie Markman, Stephen B. Howell

      Pages 39-59

3. New Drugs and New Clinical Investigation

   1. Front Matter

      Pages 61-61

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   2. Metabolites of tiazofurin as mediators of its biochemical and pharmacologic effects

      • Gurpreet S. Ahluwalia, Hiremagalur N. Jayaram, David A. Cooney

      Pages 63-102

   3. Extragonadal and central nervous system germ cell tumors: A review of diagnostic and therapeutic strategies

      • Eliot L. Friedman, Marc B. Garnick

      Pages 103-128

   4. Role of preclinical pharmacology in phase I clinical trials: Considerations of schedule-dependence

      • Jerry M. Collins, Brian Leyland-Jones, Charles K. Grieshaber

      Pages 129-140

   5. Interferon: Current concepts of mechanisms of action

      • Paul P. Trotta, Robert J. Spiegel

      Pages 141-159

   6. Acivicin: A new antimetabolite

      • Robert H. Earhart

      Pages 161-181

4. Specific Therapeutic Landmarks

   1. Front Matter

      Pages 183-183

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   2. Chemotherapy for malignant intracranial tumors

      • Paul L. Kornblith, Michael Walker

      Pages 185-203

   3. New antiviral compounds and impact in management of neoplastic disease and AIDS

      • Abraham Chachoua, Michael Green

      Pages 205-232

   4. The clinical horizon of deoxycoformycin

      • Peter J. O’Dwyer, Brian Leyland-Jones, Daniel F. Hoth

      Pages 233-255

5. Back Matter

   Pages 257-267

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Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfor­ tunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung can­ cer, genitourinary cancer, pediatric oncology, etc. Second, by asking emi­ nent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

• DNA
• Staging
• Tumor
• biology
• cancer treatment
• cell
• clinical trial
• diagnosis
• interferon
• pharmacology

• University of Southern California Cancer Centre, Los Angeles, USA

  F. M. Muggia

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