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Handbook of Copper Pharmacology and Toxicology

  • Book
  • © 2002

Overview

Editors:
  1. Edward J. Massaro

    1. The National Health and Environmental Effects Research Laboratory, Research Triangle Park, USA

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Table of contents (35 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Copper in Mammals

    1. Front Matter

      Pages 1-1
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    2. Biochemistry and Molecular Biology of Copper in Mammals

      • Maria C. Linder
      Pages 3-32

  3. Copper Proteins

    1. Front Matter

      Pages 33-33
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    2. Biochemistry of the Wilson’s Disease Protein

      • Svetlana Lutsenko, Ruslan Tsivkovskii, Matthew J. Cooper, Brian C. Macarthur, Hans-Peter Bächinger
      Pages 35-51

    3. Biologically Relevant Properties of Copper-Containing Proteins Analyzed by Means of Semiquantitative and Quantitative Theoretical Descriptors

      • Francesca De Rienzo, R. Razif Gabdoulline, Rebecca C. Wade, M. Cristina Menziani
      Pages 53-80

    4. Molecular Modeling and Dynamics of Copper Proteins

      • Mattia Falconi, Alessandro Desideri
      Pages 81-101

    5. The Prion Protein and Copper

      • Lesley R. Brown, David A. Harris
      Pages 103-113

    6. Prion Protein

      • David R. Brown
      Pages 115-129

    7. Cytochrome-c Oxidase

      • Shinya Yoshikawa
      Pages 131-152

    8. The Fet3 Protein

      • Daniel J. Kosman
      Pages 153-175

    9. Interaction of Copper-Binding Proteins from Enterococcus hirae

      • Paul A. Cobine, Christopher E. Jones, Wasantha A. Wickramasinghe, Marc Solioz, Charles T. Dameron
      Pages 177-186

  4. Copper Transport

    1. Front Matter

      Pages 187-187
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    2. Copper Uptake in Eukaryotic Cells

      • Lisbeth Birk Møller, Nina Horn
      Pages 189-199

    3. The Role of PINA in Copper Transport, Circadian Rhythms, and Wilson’s Disease

      • Jimo Borjigin, Xing Sun, Michael M. Wang
      Pages 201-207

    4. The Identification of Motifs Involved in the Intracellular Trafficking of the Menkes Disease Protein

      • Michael J. Francis, Anthony P. Monaco
      Pages 209-226

    5. Intracellular Copper Transport and ATP7B, the Wilson’s Disease Protein

      • Kunihiko Terada, Toshihiro Sugiyama
      Pages 227-234

    6. A Multicopper Oxidase-Based Iron-Transport System in Yeast

      • Jerry Kaplan
      Pages 235-245

  5. Molecular Pathogenesis of Diseases of Copper Metabolism

    1. Front Matter

      Pages 247-247
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    2. Molecular Basis of Diseases of Copper Homeostasis

      • Julian F. B. Mercer, David Kramer, James Camakaris
      Pages 249-276
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Keywords

About this book

Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases, Menkes and Wilson's diseases and occipital horn syndrome, as well as the role of copper in Parkinson's disease, prion disease, familial amytrophic lateral sclerosis (ALS), and Alzheimer's disease.

Reviews

"...biochemical and molecular researchers from around the globe have produced 35 chapters documenting the present state of knowledge in selected areas of copper pharmacology and toxicology. the state-of-the-art data provided will no doubt stimulate challenging research with this essential trace element required by organism ranging from bacteria to mammals." - Veterinary and Human Toxicology

"The book has excellent introductory chapters, and summarizes much recent research at the genetic and cellular levels." - Newsletter of the British Toxicological Society

"Dr. Massaro must be congratulated for editing this comprehensive book on copper. There are so many outstanding chapters in this compendium that highlighting any one of them should not detract from the others...this book is a treasure trove of references. The price of the book, though modest for this compendium would be justified for the Preface and the first chapter alone. This book is highly recommended. At the present time it has no equal." -International Journal of Toxicology

Editors and Affiliations

  • The National Health and Environmental Effects Research Laboratory, Research Triangle Park, USA

    Edward J. Massaro

Bibliographic Information

  • Book Title: Handbook of Copper Pharmacology and Toxicology

  • Editors: Edward J. Massaro

  • DOI: https://doi.org/10.1007/978-1-59259-288-3

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-89603-943-8Published: 01 July 2002

  • Softcover ISBN: 978-1-61737-266-7Published: 05 November 2010

  • eBook ISBN: 978-1-59259-288-3Published: 01 July 2002

  • Edition Number: 1

  • Number of Pages: XVI, 608

  • Number of Illustrations: 114 b/w illustrations

  • Topics: Pharmacology/Toxicology

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