Biological and Hormonal Therapies of Cancer

1. Front Matter

   Pages i-xiii

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2. Interferon therapy of hematologic malignancies

   • Kenneth A. Foon

   Pages 1-21

3. Interferon use in solid tumors

   • William J. John, Kenneth A. Foon

   Pages 23-33

4. Cellular vaccine therapies for cancer

   • Michael J. Mastrangelo, Takami Sato, Edmund C. Lattime, Henry C. Maguire Jr., David Berd

   Pages 35-50

5. Anti-idiotype antibody vaccine therapies of cancer

   • Malaya Bhattacharya-Chatterjee, Kenneth A. Foon

   Pages 51-68

6. Endocrine therapy of prostate cancer

   • Rick L. Bare, Frank M. Torti

   Pages 69-87

7. Endocrine therapy of endometrial cancer

   • Samuel S. Lentz

   Pages 89-106

8. Phytochemicals for the prevention of breast and endometrial cancer

   • J. Mark Cline, Claude L. Hughes Jr.

   Pages 107-134

9. Hormonal strategies for the prevention of breast cancer

   • Mark R. Olsen, Richard R. Love

   Pages 135-157

10. Ovarian ablation as adjuvant therapy for early-stage breast cancer

    • Kathleen I. Pritchard

    Pages 159-180

11. The duration of adjuvant tamoxifen therapy

    • Malcolm M. Bilimoria, V. Craig Jordan

    Pages 181-193

12. Tamoxifen and the endometrium

    • Richard R. Barakat

    Pages 195-207

13. Hormone replacement therapy and nonhormonal control of menopausal symptoms in breast cancer survivors

    • Melody A. Cobleigh

    Pages 209-230

14. Endocrine therapy in metastatic breast cancer

    • Gretchen G. Kimmick, Hyman B. Muss

    Pages 231-254

15. The regulation of estrogen receptor expression and function in human breast cancer

    • Anne T. Ferguson, Rena G. Lapidus, Nancy E. Davidson

    Pages 255-278

16. Back Matter

    Pages 279-286

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This volume, Biological and Hormonal Therapies of Cancer, which is part of the series Cancer Treatment and Research, presents selected new information concerning biologic and hormonal therapy of cancer. We have attempted to provide the reader with topics of major interest in a timely fashion. There is renewed interest in biologic therapy of cancer. Two chapters review the role of interferon in the hematologic malignancies and in solid tumors. Vaccine therapies have come to the forefront of cancer therapy re­ cently, and two chapters approach different strategies of vaccine therapies; one reviews the cellular vaccine therapies and another the anti-idiotype ap­ proach. The hormonal therapy chapters focus on current uses of endocrine therapy in endometrial, breast, and prostate cancer. In addition, hormonal strategies for the prevention of breast cancer and endometrial cancer, including excit­ ing information relating to phytochemicals, are presented. The effects of tamoxifen on endometrium is a topic of major interest and is discussed in detail. Finally, there is a chapter on estrogen receptor expression and regula­ tion in human breast cancer. These chapters are all written by experts in the field and contain timely and relevant information of interest to laboratory and clinical scientists and practitioners alike. Biologic and endocrine therapies represent major areas of cancer research interest. The advent of newer biologic therapies, including new antibody­ targeted treatments, and the use of biologics as tumor modulators to enhance the effects of other treatment regimens is an exploding avenue of research.

• Tumor
• adjuvant therapy
• endometrium
• hormones
• interferon
• prevention
• prostate cancer

• Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, USA

  Kenneth A. Foon

• College of Medicine, Vermont Cancer Center, University of Vermont, Burlington, USA

  Hyman B. Muss

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