Nucleic Acid Switches and Sensors

Editors: Silverman, Scott K. (Ed.)

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About this book

In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.

Table of contents (7 chapters)

  • Allosteric Ribozymes as Molecular Switches and Sensors

    Soukup, Garrett A.

    Pages 3-24

    Preview Buy Chapter 30,19 €
  • Ribozymes and Deoxyribozymes Switched by Oligonucleotides

    Sen, Dipankar (et al.)

    Pages 25-36

    Preview Buy Chapter 30,19 €
  • Ribozymes Switched by Proteins

    Inoue, Tan (et al.)

    Pages 37-47

    Preview Buy Chapter 30,19 €
  • Fluorescence-Signaling Nucleic Acid-Based Sensors

    Nutiu, Razvan (et al.)

    Pages 49-72

    Preview Buy Chapter 30,19 €
  • Protein-Induced RNA Switches in Nature

    Mayer, Oliver (et al.)

    Pages 75-86

    Preview Buy Chapter 30,19 €

Buy this book

eBook 118,99 €
price for Spain (gross)
  • ISBN 978-0-387-47257-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
  • ISBN 978-0-387-37491-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 145,78 €
price for Spain (gross)
  • ISBN 978-1-4419-4248-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Nucleic Acid Switches and Sensors
Editors
  • Scott K. Silverman
Copyright
2006
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-47257-7
DOI
10.1007/978-0-387-47257-7
Hardcover ISBN
978-0-387-37491-8
Softcover ISBN
978-1-4419-4248-7
Edition Number
1
Number of Pages
IX, 125
Number of Illustrations
54 b/w illustrations, 3 illustrations in colour
Topics