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Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells

  • Book
  • © 1990

Overview

Editors:
  1. Francisco J. Alvarez-Leefmans

    1. Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, Mexico, USA
      Departamento de Neurobiología, Instituto Mexicano de Psiquiatría, Mexico, USA

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  2. John M. Russell

    1. Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, USA

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About this book

This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s assigned Cl- a ther­ modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and the extracellular fluid. Second, work on Cl- transport in red blood cells confirmed that the Cl- transmembrane distribution was thermodynamically passive and, in addition, showed that Cl- crossed the mem­ brane extremely rapidly. This latter finding [for a long time interpreted as being the result of a high passive chloride electrical permeability(? CI)] made it quite likely that Cl- would remain at thermodynamic equilibrium. These two observations were gener­ alized and virtually all cells were thought to have a very high P Cl and a ther­ modynamically passive Cl- transmembrane distribution. These concepts can still be found in some physiology and neuroscience textbooks.

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Chloride Carriers

    1. Front Matter

      Pages 1-1
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    2. Methods for Measuring Chloride Transport across Nerve, Muscle, and Glial Cells

      • Francisco J. Alvarez-Leefmans, Fernando Giraldez, John M. Russell
      Pages 3-66

    3. Principles of Cell Volume Regulation Ion Flux Pathways and the Roles of Anions

      • Peter M. Cala
      Pages 67-83

    4. Chloride Transport in the Squid Giant Axon

      • John M. Russell, Walter F. Boron
      Pages 85-107

    5. Intracellular Cl− Regulation and Synaptic Inhibition in Vertebrate and Invertebrate Neurons

      • Francisco J. Alvarez-Leefmans
      Pages 109-158

    6. Chloride Transport across Glial Membranes

      • H. K. Kimelberg
      Pages 159-191

    7. Chloride Channels and Carriers in Cultured Glial Cells

      • H. Kettenmann
      Pages 193-208

    8. Chloride Transport across the Sarcolemma of Vertebrate Smooth and Skeletal Muscle

      • C. Claire Aickin
      Pages 209-249

  3. Different Types of Cl− Channels

    1. Front Matter

      Pages 251-251
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    3. Ca2+-Activated Cl− Channels

      1. Calcium-Dependent Chloride Currents in Vertebrate Central Neurons
        • Mark L. Mayer, David G. Owen, Jeffrey L. Barker
        Pages 355-364

    4. Voltage-Activated Cl− Channels

      1. Hyperpolarization-Activated Chloride Channels in Aplysia Neurons
        • Dominique Chesnoy-Marchais
        Pages 367-382
      2. The Voltage-Dependent Chloride Channel of Torpedo Electroplax
        • Christopher Miller, Edwin A. Richard
        Pages 383-405
      3. Chloride Channels in Skeletal Muscle
        • Andrew L. Blatz
        Pages 407-420

  4. Back Matter

    Pages 421-425
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Editors and Affiliations

  • Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, Mexico, USA

    Francisco J. Alvarez-Leefmans

  • Departamento de Neurobiología, Instituto Mexicano de Psiquiatría, Mexico, USA

    Francisco J. Alvarez-Leefmans

  • Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, USA

    John M. Russell

Bibliographic Information

  • Book Title: Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells

  • Editors: Francisco J. Alvarez-Leefmans, John M. Russell

  • DOI: https://doi.org/10.1007/978-1-4757-9685-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1990

  • Hardcover ISBN: 978-0-306-43426-6Published: 31 May 1990

  • Softcover ISBN: 978-1-4757-9687-2Published: 27 April 2013

  • eBook ISBN: 978-1-4757-9685-8Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: XVIII, 426

  • Topics: Animal Physiology, Biological and Medical Physics, Biophysics, Neurosciences

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