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Microbial Communication

Mathematical Modeling, Synthetic Biology and the Role of Noise

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  • © 2020

Overview

  • Elaborates on all the different kinds of microbial communication systems
  • Describes the role of noise in the context of microbial communication
  • Provides insights into the mathematical models, experimental observations, synthetic biology and the relevance of quantum theory in understanding microbial communication

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Table of contents (15 chapters)

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About this book

This book introduces the concept of bacterial communication systems from a mathematical modeling point of view. It sheds light on the research undertaken in the last three decades, and the mathematical models that have been proposed to understand the underlying mechanism of such systems. These communication systems are related to quorum sensing mechanisms and quorum sensing regulated processes such as biofilm formation, gene expression, bioluminescence, swarming and virulence. 

The book further describes the phenomenon of noise, and discusses how noise plays a crucial role in gene expression and the quorum sensing circuit operationusing a set of tools like frequency domain analysis, power spectral density, stochastic simulation and the whitening effect. It also explores various aspects of synthetic biology (related to bacterial communication), such as genetic toggle switch, bistable gene regulatory networks, transcriptional repressor systems, pattern formation, syntheticcooperation, predator-prey synthetic systems, dynamical quorum sensing, synchronized quorum of genetic clocks, role of noise in synthetic biology, the Turing test and stochastic Turing test.



Authors and Affiliations

  • Dipartimento di Ingegneria e Scienze dell’Informazione e Matematica, Università degli Studi dell’Aquila, L’Aquila, Italy

    Sarangam Majumdar

  • IISC Campus, National Institute of Advanced Studies, Bangalore, India

    Sisir Roy

About the authors

Sarangam Majumdar is a mathematician. He holds a Bachelor of Science and Master of Science in Mathematics from the University of Calcutta (2010) and National Institute of Technology, Rourkela (2012), respectively. He has worked with Prof. Sisir Roy, Indian Statistical Institute, Kolkata; Prof. Rodolfo Llinas, New York University School of Medicine, USA; Prof. Dr. Suman Datta, University of Calcutta; Prof. S. Chakraverty, National Institute of Technology, Rourkela; Dr. Sukla Pal, University of Otago,NewZeland; Prof. Rodolfo Repetto, Dipartimento di Ingegneriadelle Costruzioni, dell'Ambiente e del Territorio, Università degl iStudi di Genova, Italy; Prof. Nicola Guglielmi, Università degli Studi di L' Aquila and many more. His research interests include mathematical biology, system biology, mathematical modeling, numerical analysis, scientific computing, nonlinear dynamics and chaos, and over the past eight yearshe has focused on bacterial communication systems (quorum sensing, electrical communication). He has published several papers in various peer-reviewed, international journals and book chapters (in Springer). He is also a reviewer for a number of international journals.



Prof. Sisir Roy is a theoretical physicist currently working as a Visiting Professor and Senior Homi Bhabha Fellow, National Institute of Advanced Studies, IISc Campus, Bangalore. Previously he worked as a Professor at the Physics and Applied Mathematics Unit, Indian Statistical Institute, Kolkata from 1980 to 2014, and as a Visiting Scientist at the Institute Henri Poincare, Paris, France, from 1986 to 87. He has also worked as a Distinguished Visiting Professor at numerous US and European Universities. He has collaborated with Prof. J.P. Vigier, France; Prof. Bo Lehnert, Alfven Laboratory, Sweden; Prof. Menas Kafatos, George Mason University; Prof. Ralph Abraham, University of California; and Prof. Rodolfo Llinas, New York University School of Medicine, NY,USA. Hismain interests includethe foundations of quantum theory, theoretical astrophysics, quantum biology, brain function modeling and higher-order cognitive activities. He has published more than two hundred papers in various peer-reviewed, international journals, twelve monographs and edited volumes published by Kluwer Academic Publishers, World Scientific, Singapore, Springer and others.  He is currently a member of the editorial boards of various international journals. His recent books include: Sisir Roy (2016) Decision making and modeling in cognitive science, Springer




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