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SpringerBriefs in Philosophy
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Evaluating Evidence of Mechanisms in Medicine

Principles and Procedures

Authors: Parkkinen, V.-P., Wallmann, C., Wilde, M., Clarke, B., Illari, P., Kelly, M.P., Norell, C., Russo, F., Shaw, B., Williamson, J.

  • The only book to develop explicit procedures for evaluating evidence of mechanisms
  • Contains a philosophical justification of these procedures
    Extends and improves the tools available to Evidence-Based Medicine (EBM)
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eBook  
  • ISBN 978-3-319-94610-8
  • This book is an open access book, you can download it for free on link.springer.com
Softcover £17.99
price for United Kingdom (gross)
  • ISBN 978-3-319-94609-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book is open access under a CC BY license. 

This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. 

Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. 

The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.

About the authors

The authors of this book are members of EBM+ (ebmplus.org), a network of researchers investigating the role of evidence of mechanisms in the health sciences. During the writing of this book, Parkkinen, Wallmann, Wilde and Williamson were based at the Centre for Reasoning, University of Kent; Clarke, Illari and Norell at the Department of Science and Technology Studies, UCL; Kelly at the Department of Public Health and Primary Care, University of Cambridge; Russo at the Department of Philosophy, University of Amsterdam; and Shaw at the National Institute of Health and Care Excellence, UK. This research way supported by the UK Arts and Humanities Research Council and the Leverhulme Trust.

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Introduction

    Pages 3-9

    Parkkinen, Veli-Pekka (et al.)

  • An Introduction to Mechanisms

    Pages 11-21

    Parkkinen, Veli-Pekka (et al.)

  • How to Consider Evidence of Mechanisms: An Overview

    Pages 23-33

    Parkkinen, Veli-Pekka (et al.)

  • Tools

    Pages 37-59

    Parkkinen, Veli-Pekka (et al.)

  • Gathering Evidence of Mechanisms

    Pages 63-75

    Parkkinen, Veli-Pekka (et al.)

Buy this book

eBook  
  • ISBN 978-3-319-94610-8
  • This book is an open access book, you can download it for free on link.springer.com
Softcover £17.99
price for United Kingdom (gross)
  • ISBN 978-3-319-94609-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Evaluating Evidence of Mechanisms in Medicine
Book Subtitle
Principles and Procedures
Authors
Series Title
SpringerBriefs in Philosophy
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
The Editor(s) (if applicable) and The Author(s)
eBook ISBN
978-3-319-94610-8
DOI
10.1007/978-3-319-94610-8
Softcover ISBN
978-3-319-94609-2
Series ISSN
2211-4548
Edition Number
1
Number of Pages
XVIII, 125
Number of Illustrations
14 b/w illustrations
Topics