Evaluating Evidence of Mechanisms in Medicine
Principles and Procedures
Authors: Parkkinen, V.-P., Wallmann, C., Wilde, M., Clarke, B., Illari, P., Kelly, M.P., Norell, C., Russo, F., Shaw, B., Williamson, J.
- The only book to develop explicit procedures for evaluating evidence of mechanisms
- Contains a philosophical justification of these procedures
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- About this book
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This book is open access under a CC BY license.
This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness.
Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions.
The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.
- About the authors
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The authors of this book are members of EBM+ (ebmplus.org), a network of researchers investigating the role of evidence of mechanisms in the health sciences. During the writing of this book, Parkkinen, Wallmann, Wilde and Williamson were based at the Centre for Reasoning, University of Kent; Clarke, Illari and Norell at the Department of Science and Technology Studies, UCL; Kelly at the Department of Public Health and Primary Care, University of Cambridge; Russo at the Department of Philosophy, University of Amsterdam; and Shaw at the National Institute of Health and Care Excellence, UK. This research way supported by the UK Arts and Humanities Research Council and the Leverhulme Trust.
- Video
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- Table of contents (10 chapters)
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Introduction
Pages 3-9
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An Introduction to Mechanisms
Pages 11-21
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How to Consider Evidence of Mechanisms: An Overview
Pages 23-33
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Tools
Pages 37-59
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Gathering Evidence of Mechanisms
Pages 63-75
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Table of contents (10 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Evaluating Evidence of Mechanisms in Medicine
- Book Subtitle
- Principles and Procedures
- Authors
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- Veli-Pekka Parkkinen
- Christian Wallmann
- Michael Wilde
- Brendan Clarke
- Phyllis Illari
- Michael P Kelly
- Charles Norell
- Federica Russo
- Beth Shaw
- Jon Williamson
- Series Title
- SpringerBriefs in Philosophy
- Copyright
- 2018
- Publisher
- Springer International Publishing
- Copyright Holder
- The Editor(s) (if applicable) and The Author(s)
- eBook ISBN
- 978-3-319-94610-8
- DOI
- 10.1007/978-3-319-94610-8
- Softcover ISBN
- 978-3-319-94609-2
- Series ISSN
- 2211-4548
- Edition Number
- 1
- Number of Pages
- XVIII, 125
- Number of Illustrations
- 14 b/w illustrations
- Topics
