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Varicocele and Male Infertility

A Complete Guide

  • Textbook
  • © 2019

Overview

Editors:
  1. Sandro C Esteves

    1. ANDROFERT, Andrology & Human Reproduction Clinic, Campinas, Brazil

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  2. Chak-Lam Cho

    1. S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong

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  3. Ahmad Majzoub

    1. Department of Urology, Hamad Medical Corporation, Weill Cornell Medicine Qatar, Doha, Qatar

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  4. Ashok Agarwal

    1. Department of Urology, Cleveland Clinic, Cleveland, USA

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  • A unique textbook presenting a thoughtful and comprehensive view of the significance of varicocele and its impact in male fertility, including medical and surgical management

  • Includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and ART, controversies and case material

  • An invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility

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Table of contents (58 chapters)

  1. Front Matter

    Pages i-xxvii
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  2. Varicocele Origin and Pathophysiology

    1. Front Matter

      Pages 1-1
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    2. The Evolution and Refinement of Varicocele Treatment: A Historical Perspective

      • Joel L. Marmar
      Pages 3-16

    3. Anatomic Theories of Varicocele Origin

      • Neel Parekh, Edmund Sabanegh Jr.
      Pages 17-26

    4. Scrotal Hyperthermia, Hormonal Disturbances, Testicular Hypoperfusion, and Backflow of Toxic Metabolites in Varicocele

      • Ahmad Majzoub, Chak-Lam Cho, Ashok Agarwal, Sandro C. Esteves
      Pages 27-35

    5. Genetics and Epigenetics of Varicocele Pathophysiology

      • Viviane Paiva Santana, Cristiana Libardi Miranda-Furtado, Rosana Maria dos Reis
      Pages 37-53

    6. Oxidative Stress and Varicocele Pathophysiology

      • Ahmad Majzoub, Chak-Lam Cho, Ashok Agarwal, Sandro C. Esteves
      Pages 55-71

    7. Proteomic and Metabolomic Profile of Semen and Seminal Plasma in Varicocele

      • Manesh Kumar Panner Selvam, Ashok Agarwal
      Pages 73-85

    8. Experimental Varicocele

      • Fatima Kazue Okada, Renata Cristina de Carvalho, Ricardo Pimenta Bertolla
      Pages 87-94

  3. Clinical Evaluation of Varicocele

    1. Front Matter

      Pages 95-95
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    2. Epidemiology of Varicocele in Pediatric, Adolescent, and Adult Populations

      • Mohannad Alharbi, Armand Zini
      Pages 97-106

    3. Association Between Varicocele and Infertility

      • Daniel Lybbert, Nicholas N. Tadros
      Pages 107-114

    4. Varicocele Clinical Diagnosis and Grading

      • Mohamed Arafa, Haitham Elbardisi
      Pages 115-121

    5. Imaging and Other Diagnostic Modalities in Varicocele Diagnosis

      • Muhannad M. Alsyouf, Phillip K. Stokes, Edmund Y. Ko
      Pages 123-135

    6. Conventional Semen Analysis and Specialized Sperm Function Tests in Patients with Varicocele

      • Ahmad Majzoub, Chak-Lam Cho, Ashok Agarwal, Sandro C. Esteves
      Pages 137-157

    7. Endocrine Testing and the Association Between Varicocele and Hypogonadism

      • Grace Yaguchi, Ali A. Dabaja
      Pages 159-169

    8. Varicocele and Orchialgia

      • Benjamin J. McCormick, R. Matthew Coward
      Pages 171-182

  4. Varicocele Therapy

    1. Front Matter

      Pages 183-183
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    2. Medical Therapy in Varicocele-Related Infertility

      • Gian Maria Busetto, Francesco Del Giudice, Ettore De Berardinis
      Pages 185-199

    3. Macroscopic Surgical Techniques for Varicocele Repair

      • Sarah C. Krzastek, Connor Rotterman, Ryan P. Smith, Jason R. Kovac
      Pages 201-208
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Keywords

About this book

This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and assisted reproductive technology (ART). Repair of varicocele, which can be carried out by various methods, not only alleviates oxidative stress‐associated infertility but also prevents and protects against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress. 

Even with the advances in the understanding of this intriguing disease and consensus on some areas such as diagnosis and pathophysiology, substantial controversy still exists, in particular concerning the benefits of treatment and to whom treatment should be offered. Additional chapters discuss, in depth, such controversies surrounding the role of varicocele in male infertility and present clinical case scenarios dealing with management of subclinical and clinical varicocele. A series of editorial comments is provided by the editors at the end of selected chapters, containing an objective and concise summary of the information from each chapter. In addition, chapters open up with key points for quick references and conclude with multiple choice questions and answers for immediate review and retention of the rich content.

Generously illustrated, Varicocele and Male Infertility: A Complete Guide represents an invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility (e.g., urologists, gynecologists, reproductive endocrinologists, and embryologists) and is comprised of chapters written by leading and internationally recognized clinicians and scientists with expertise in varicocele, skillfully edited by leaders in the field.

Editors and Affiliations

  • ANDROFERT, Andrology & Human Reproduction Clinic, Campinas, Brazil

    Sandro C Esteves

  • S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Chak-Lam Cho

  • Department of Urology, Hamad Medical Corporation, Weill Cornell Medicine Qatar, Doha, Qatar

    Ahmad Majzoub

  • Department of Urology, Cleveland Clinic, Cleveland, USA

    Ashok Agarwal

About the editors

Sandro C. Esteves, MD, PhD

ANDROFERT

Andrology & Human Reproduction Clinic

Campinas, SP, Brazil

 

Chak-Lam Cho, FRCSED (Urol), FHKAM (Surgery)

S.H. Ho Urology Centre

Department of Surgery

Prince of Wales Hospital

The Chinese University of Hong Kong

Hong Kong.

 

Ahmad Majzoub, MD, CABU, FECSM

Department of Urology

Hamad Medical Corporation

Weill Cornell Medicine Qatar

Doha, Qatar

 

Ashok Agarwal, PhD, HCLD (ABB), ELD (ACE)

Department of Urology

Cleveland Clinic

Cleveland, OH, USA 

Bibliographic Information

  • Book Title: Varicocele and Male Infertility

  • Book Subtitle: A Complete Guide

  • Editors: Sandro C Esteves, Chak-Lam Cho, Ahmad Majzoub, Ashok Agarwal

  • DOI: https://doi.org/10.1007/978-3-319-79102-9

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-319-79101-2Published: 08 October 2019

  • eBook ISBN: 978-3-319-79102-9Published: 11 September 2019

  • Edition Number: 1

  • Number of Pages: XXVII, 638

  • Number of Illustrations: 23 b/w illustrations, 68 illustrations in colour

  • Topics: Reproductive Medicine, Andrology

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