Complement Activation in Malaria Immunity and Pathogenesis
Editors: Stoute, José A. (Ed.)
Free Preview- Unique resource that addresses the role of complement in malaria
- Written by experts from leading laboratories
- Important reference tool for malaria and complement researchers and immunologists alike
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- About this book
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Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.
- About the authors
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José A. Stoute, M.D.
Professor of Medicine, and Microbiology & Immunology
The Pennsylvania State University Hershey Medical Center and College of Medicine
- Table of contents (8 chapters)
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The Complement System
Pages 1-29
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Mechanisms of Complement Activation in Malaria
Pages 31-49
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Role of Complement in Severe Malarial Anemia
Pages 51-64
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Role of Complement in Cerebral Malaria
Pages 65-90
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Complement and Malaria in Pregnancy
Pages 91-105
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Table of contents (8 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Complement Activation in Malaria Immunity and Pathogenesis
- Editors
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- José A. Stoute
- Copyright
- 2018
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer International Publishing AG, part of Springer Nature
- eBook ISBN
- 978-3-319-77258-5
- DOI
- 10.1007/978-3-319-77258-5
- Hardcover ISBN
- 978-3-319-77257-8
- Edition Number
- 1
- Number of Pages
- XII, 149
- Number of Illustrations
- 5 b/w illustrations, 17 illustrations in colour
- Topics
