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  • © 2016

Genetics, Evolution and Radiation

Crossing Borders, The Interdisciplinary Legacy of Nikolay W. Timofeeff-Ressovsky

  • Provides an in-depth overview of the evolution of radiobiological thought, including both its history and outlook for the future
  • Offers data on the radiation effects of nuclear facilities and related accidents
  • Provides first-hand accounts of the work of Timofeeff-Ressovsky by a host of close colleagues and friends
  • Presents the evolution of the genomic universe from the perspective of radiation and genetics
  • Includes supplementary material: sn.pub/extras

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Softcover Book USD 249.99
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Table of contents (40 chapters)

  1. Front Matter

    Pages i-xx
  2. N.W. Timofeeff-Ressovsky: Science Without Borders

    1. Front Matter

      Pages 1-1
    2. Some Stories Told by N.W. Timofeeff-Ressovsky

      • Nikolay W. Timofeeff-Ressovsky
      Pages 3-12
    3. Nikolai V. Timoféeff-Ressovsky in Berlin-Buch (1925–1945)

      • Manfred Rajewsky, Dana Lafuente, Michael Bader
      Pages 13-28
  3. Genetic Processes

    1. Front Matter

      Pages 39-39
    2. Template Principle in Biology

      • Sergey G. Inge-Vechtomov
      Pages 41-54
    3. Mechanisms of Global and Region-Specific Control of Mutagenesis

      • Youri I. Pavlov, Artem G. Lada, Corinn Grabow, Elena I. Stepchenkova
      Pages 55-76
    4. Protein Assembly Disorders and Protein-Based Inheritance

      • Aleksander A. Rubel, Alsu F. Saifitdinova, Nina V. Romanova
      Pages 85-105
    5. Broadening the Genetic Diversity of Bread Wheat Using Alien Germplasm: Emphasis on Disease Resistance

      • Vladimir Shumny, Elena Khlestkina, Irina Leonova, Elena Salina
      Pages 107-120
    6. Kinase Cascade of DNA Damage Checkpoint

      • Natalia Koltovaya
      Pages 125-138
  4. Radiobiology Effects and Mechanisms

    1. Front Matter

      Pages 139-139
    2. Strategies of Adaptation Under Prolonged Irradiation vs Chronic Exposure

      • Victoria L. Korogodina, Elena B. Grigorkina, Ludmila P. Osipova
      Pages 153-167
    3. Mathematical Modeling of the DNA Double-Strand Break Repair in Mammalian and Human Cells

      • Oleg V. Belov, Marina S. Panina, Munkhbaatar Batmunkh, Nasser Sweilam
      Pages 169-174
    4. Mathematical Analysis of Regulatory Networks and Damage Repair Efficiency in Bacterial Cells

      • Aleksandr Bugay, Maria Vasilyeva, Aleksandr Parkhomenko, Evgeny Krasavin
      Pages 175-185
    5. Radiation Risks and Confusions

      • Helmut Abel, Gudrun Erzgräber
      Pages 187-191

About this book

This book is dedicated to the great scientist and outstanding individual Nikolay Wladimirovich Timofeeff-Ressovsky. The book brings together a number of brief stories/essays about Timofeeff-Ressovsky including “Stories told by himself”, and scientific chapters addressing his major research areas: genetics, radiobiology, radiation ecology and epidemiology, and evolution. Timofeeff-Ressovsky contributed to several fields of biology and established new directions of scientific research. He often repeated the phrase, which would later become famous: “Science should not be approached with the ferocity of wild animals”. In keeping with that philosophy, the issues discussed here are still open. 

Each scientific part starts with a current review; the chapters present leading scientific schools and views. The main theme discussed in the genetics part is mutation variability in the context of linear (replication, transcription, translation) and conformational template processes, and its dependence on phylogenetic group. In turn, the radiobiology chapters focus on the reorganization of DNA, cell, and population variability under low-dose irradiation, sparking indirect processes and adaptive response. The radiation ecology and epidemiology parts present data on the consequences of nuclear plants and related accidents for ecological systems and human beings. Here some approaches to estimating radiation risks are also offered. Evolution laws are demonstrated in the genomic universe, plant-microbe symbiosis, stabilizing and destabilizing (directional) selection. The last essay demonstrates the principles of organization operating in local animal populations, which are approached as social organisms of complex systemic nature.

The chapter 'Radiation-Induced Aging and Genetic Instability of Mesenchymal Stem Cells: An Issue for Late Health Effects?' is available open access under a CC BY 4.0 license.

Editors and Affiliations

  • Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia

    Victoria L. Korogodina

  • Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Canada

    Carmel E Mothersill, Colin B. Seymour

  • Genetics and Biotechnology, St. Petersburg State University, St. Petersburg, Russia

    Sergey G. Inge-Vechtomov

Bibliographic Information

Buy it now

Buying options

eBook USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access