Neural Engineering

1. Front Matter

   Pages i-viii

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2. Biomaterials and 3D Printing Techniques for Neural Tissue Regeneration

   • Se-Jun Lee, Wei Zhu, Nathan Castro, Lijie Grace Zhang

   Pages 1-24

3. Stem Cells, Bioengineering, and 3-D Scaffolds for Nervous System Repair and Regeneration

   • Elizabeth J. Sandquist, Metin Uz, Anup D. Sharma, Bhavika B. Patel, Surya K. Mallapragada, Donald S. Sakaguchi

   Pages 25-81

4. Engineering Neuronal Patterning and Defined Axonal Elongation In Vitro

   • Devon A. Bowser, Michael J. Moore

   Pages 83-121

5. Building Blocks for Bottom-Up Neural Tissue Engineering: Tools for In Vitro Assembly and Interrogation of Neural Circuits

   • Stephanie Knowlton, Dan Li, Fulya Ersoy, Yong Ku Cho, Savas Tasoglu

   Pages 123-144

6. Electrically Conductive Materials for Nerve Regeneration

   • Elisabeth M. Steel, Harini G. Sundararaghavan

   Pages 145-179

7. Bioactive Nanomaterials for Neural Engineering

   • Melike Sever, Idil Uyan, Ayse B. Tekinay, Mustafa O. Guler

   Pages 181-206

8. Cell Sources and Nanotechnology for Neural Tissue Engineering

   • Wei Zhu, Nathan Castro, Brent Harris, Lijie Grace Zhang

   Pages 207-226

9. Brain-Machine Interfaces: Restoring and Establishing Communication Channels

   • Charlie Rodenkirch, Brian Schriver, Qi Wang

   Pages 227-259

10. In Vitro Modeling of Nervous System: Engineering of the Reflex Arc

    • Xiufang Guo, Frank Sommerhage, Christopher McAleer, Candace Martin, Christopher Long, Ying Wang et al.

    Pages 261-298

11. Back Matter

    Pages 299-306

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This book covers the principles of advanced 3D fabrication techniques, stem cells and biomaterials for neural engineering. Renowned contributors cover topics such as neural tissue regeneration, peripheral and central nervous system repair, brain-machine interfaces and in vitro nervous system modeling. Within these areas, focus remains on exciting and emerging technologies such as highly developed neuroprostheses and the communication channels between the brain and prostheses, enabling technologies that are beneficial for development of therapeutic interventions, advanced fabrication techniques such as 3D bioprinting, photolithography, microfluidics, and subtractive fabrication, and the engineering of implantable neural grafts.
There is a strong focus on stem cells and 3D bioprinting technologies throughout the book, including working with embryonic, fetal, neonatal, and adult stem cells and a variety of sophisticated 3D bioprinting methods for neural engineering applications. There is also a strong focus on biomaterials, including various conductive biomaterials and biomimetic nanomaterials such as carbon-based nanomaterials and engineered 3D nanofibrous scaffolds for neural tissue regeneration. Finally, two chapters on in vitro nervous system models are also included, which cover this topic in the context of studying physiology and pathology of the human nervous system, and for use in drug discovery research. This is an essential book for biomedical engineers, neuroscientists, neurophysiologists, and industry professionals.

• 3D Bioprinting
• Additive Manufacturing
• Conductive Biomaterials
• Electrospinning for Central Nervous System
• Nerve Guidance Conduit
• Nerve Regeneration
• Neural Biomaterials
• Neural Engineering
• Neural Nanomaterials
• Neurotropic Factor Delivery Systems

• & Aero Eng., Biomed.Eng & Medicine, The George Washington Univ.,Dept of Mech, Washington, USA

  Lijie Grace Zhang

• Dept of Biomedical Engineering, Tufts University,Stern Family Prof., Medford, USA

  David L. Kaplan

Lijie Grace Zhang is Associate Professor in the School of Engineering and Applied Science at The George Washington University, and is Director of the Bioengineering Laboratory for Nanomedicine and Tissue Engineering. She is also Associate Editor-in-Chief of International Journal of Nanomedicine. 


David Kaplan holds an Endowed Chair, the Stern Family Professor of Engineering, at Tufts University. He is Professor and Chair of the Department of Biomedical Engineering and also holds faculty appointments in the School of Medicine, the School of Dental Medicine, Department of Chemistry, and the Department of Chemical and Biological Engineering. He serves on the editorial boards of numerous journals and is Associate Editor for the ACS journal Biomacromolecules.

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