SpringerBriefs in Biometals

Metal Response in Cupriavidus metallidurans

Volume I: From Habitats to Genes and Proteins

Editors: Mergeay, Max, Van Houdt, Rob (Eds.)

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  • A detailed overview of the diversity of metal resistance and homeostasis systems
  • Their general context related to mobile genetic elements and horizontal gene transfer
  • The underlying regulatory network and crosstalk within this network  
  • Catalytic and three-dimensional structural insights
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eBook £35.99
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  • ISBN 978-3-319-20594-6
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Softcover £44.99
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About this book

This book is the first volume of a two-volume set summarizing 40 years of key research findings directly related to metal-resistant Cupriavidus/Ralstonia (Betaproteobacteria). In this first volume, the historical and geographical context of these bacteria, which are mostly found in industrial and polluted environments linked to zinc and other non-ferrous metallurgy, is sketched to illustrate the interactions between bacteria and human activities and the possible evolutionary consequences on bacterial genomes especially as far as the association of metal resistance genes with mobile genetic elements is concerned. A detailed description of the response and underlying genetic determinants of type strain Cupriavidus metallidurans CH34 to a variety of metals is provided. With high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification carried by its megaplasmids pMOL28 and pMOL30. This description is complemented with the genomic context of the metal response genes in C. metallidurans CH34 with a focus on its mobilome including insertion sequence elements, transposons, integrative and conjugative elements and genomic islands. In addition, in the second volume, structural and catalytic data from bacterial primary and secondary transporters (P-ATPases, tripartite chemiosmotic cation/proton efflux systems, cation diffusion facilitators, Major Facilitator Superfamily and some minor categories) are outlined and detailed for the corresponding C. metallidurans proteins. The available three-dimensional structures of C. metallidurans proteins are reviewed in detail, including RND and membrane fusion proteins (from tripartite chemiosmotic cation/proton efflux systems), sigma and anti-sigma regulatory proteins of the cnr efflux system (resistance to cobalt and nickel) and various periplasmic proteins mainly involved in the response to copper and mercury.

Table of contents (3 chapters)

Table of contents (3 chapters)
  • The History of Cupriavidus metallidurans Strains Isolated from Anthropogenic Environments

    Pages 1-19

    Mergeay, Max

  • Genomic Context of Metal Response Genes in Cupriavidus metallidurans with a Focus on Strain CH34

    Pages 21-44

    Van Houdt, Rob (et al.)

  • Response of Cupriavidus metallidurans CH34 to Metals

    Pages 45-89

    Monsieurs, Pieter (et al.)

Buy this book

eBook £35.99
price for United Kingdom (gross)
  • ISBN 978-3-319-20594-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Softcover £44.99
price for United Kingdom (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Metal Response in Cupriavidus metallidurans
Book Subtitle
Volume I: From Habitats to Genes and Proteins
Editors
  • Max Mergeay
  • Rob Van Houdt
Series Title
SpringerBriefs in Biometals
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
The Author(s)
eBook ISBN
978-3-319-20594-6
DOI
10.1007/978-3-319-20594-6
Softcover ISBN
978-3-319-20593-9
Series ISSN
2212-9901
Edition Number
1
Number of Pages
IX, 89
Number of Illustrations
9 illustrations in colour
Topics