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Handbook of Experimental Pharmacology

Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

Editors: Moore, Philip K., Whiteman, Matt (Eds.)

  • ​A recently discovered biological entity attracting growing interest from academics worldwide
  • Plays key roles in normal physiological processes whilst aberrant biosynthesis can lead, or contribute to, disease states
  • Growing impact within the pharmaceutical interest in drugs which manipulate its synthesis or activity
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eBook £183.50
price for United Kingdom (gross)
  • ISBN 978-3-319-18144-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover £249.99
price for United Kingdom (gross)
  • ISBN 978-3-319-18143-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover £229.99
price for United Kingdom (gross)
  • ISBN 978-3-319-35909-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.

Table of contents (18 chapters)

  • H2S Synthesizing Enzymes: Biochemistry and Molecular Aspects

    Huang, Caleb Weihao (et al.)

    Pages 3-25

  • Persulfidation (S-sulfhydration) and H2S

    Filipovic, Milos R.

    Pages 29-59

  • Physiological Roles of Hydrogen Sulfide and Polysulfides

    Kimura, Hideo

    Pages 61-81

  • H2S and Blood Vessels: An Overview

    Yang, Guangdong (et al.)

    Pages 85-110

  • Hydrogen Sulfide and Urogenital Tract

    Villa Bianca, Roberta d’Emmanuele (et al.)

    Pages 111-136

Buy this book

eBook £183.50
price for United Kingdom (gross)
  • ISBN 978-3-319-18144-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover £249.99
price for United Kingdom (gross)
  • ISBN 978-3-319-18143-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover £229.99
price for United Kingdom (gross)
  • ISBN 978-3-319-35909-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide
Editors
  • Philip K. Moore
  • Matt Whiteman
Series Title
Handbook of Experimental Pharmacology
Series Volume
230
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-18144-8
DOI
10.1007/978-3-319-18144-8
Hardcover ISBN
978-3-319-18143-1
Softcover ISBN
978-3-319-35909-0
Series ISSN
0171-2004
Edition Number
1
Number of Pages
VI, 395
Number of Illustrations and Tables
145 b/w illustrations, 27 illustrations in colour
Topics