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Molecular Mechanisms Underpinning the Development of Obesity

  • Book
  • © 2014

Overview

Editors:
  1. Clévio Nóbrega

    1. Cntr for Neurosciences and Cell Biology University of Coimbra, Coimbra, Portugal

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  2. Raquel Rodriguez-López

    1. Nutrition and Gastroenterology Department, Armand-Trousseau Hospital, Valencia, Spain

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Offers a comprehensive review of efforts aimed at uncovering genetic variants associated with obesity

  • Reviews genome-wide association studies, along with studies on monogenic and polygenic obesity

  • Identifies the most promising research areas, methods, and strategies for use in future efforts to understand the genetic basis of obesities and their consequences on human health, including nutrigenomics

  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. Challenges in Understanding Development of Obesity

    • Thorkild I.A. Sørensen
    Pages 1-7

  3. Monogenic Forms of Obesity

    • Hèléne Huvenne, Béatrice Dubern
    Pages 9-21

  4. Heterogeneous Obesity Syndromes: New Strategies for Diagnosis

    • Raquel Rodríguez-López
    Pages 23-35

  5. Genetic Contribution: Common Forms of Obesity

    • David Albuquerque, Clévio Nóbrega
    Pages 37-55

  6. The Role of the GWAS Identified FTO Locus in Regulating Body Size and Composition

    • Giles S. H. Yeo
    Pages 57-72

  7. Neural Vulnerability Factors that Increase Risk for Weight Gain: Prevention and Treatment Implications

    • Eric Stice, Sonja Yokum, Kyle Burger
    Pages 73-86

  8. Molecular Mechanisms Involved in the Regulation of Food Intake

    • Emilio González-Jiménez
    Pages 87-100

  9. Epigenetics of Human Obesity: A Link Between Genetics and Nutrition

    • David Albuquerque, Licínio Manco, Clévio Nóbrega
    Pages 101-127

  10. MicroRNAs in Obesity and Metabolism

    • Lígia Sousa-Ferreira, Luís Pereira de Almeida, Cláudia Cavadas
    Pages 129-152

  11. Obesity Study: Animal Models

    • Goro Katsuura, Namiko Kawamura, Miyuki Nishida, Haruka Amitani, Akihiro Asakawa, Akio Inui
    Pages 153-166

  12. From Homo Obesus to Homo Diabesus: Neuroadipology Insight

    • George N. Chaldakov, Luigi Aloe, Anton B. Tonchev, Marco Fiore
    Pages 167-178

  13. Obesity and Type 2 Diabetes

    • Charbel Abi Khalil, Shahrad Taheri
    Pages 179-194
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Keywords

About this book

Obesity is a multi-factorial disease, in which an excess of accumulated body fat can reach levels capable of affecting health. It results from an interplay between environmental factors, eating behavior, genes, epigenetics, and neuronal stimuli. The main aim of this book is to provide a state-of-the-art revision about the molecular mechanisms underpinning the development of obesity, reviewing the current knowledge in areas like monogenic and polygenic obesity forms, but also providing an updated view of the emerging knowledge about epigenetics, nutrigenomics, and neuronal aspects that also contribute to obesity.

Editors and Affiliations

  • Cntr for Neurosciences and Cell Biology University of Coimbra, Coimbra, Portugal

    Clévio Nóbrega

  • Nutrition and Gastroenterology Department, Armand-Trousseau Hospital, Valencia, Spain

    Raquel Rodriguez-López

Bibliographic Information

  • Book Title: Molecular Mechanisms Underpinning the Development of Obesity

  • Editors: Clévio Nóbrega, Raquel Rodriguez-López

  • DOI: https://doi.org/10.1007/978-3-319-12766-8

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2014

  • Hardcover ISBN: 978-3-319-12765-1Published: 30 December 2014

  • Softcover ISBN: 978-3-319-37629-5Published: 10 September 2016

  • eBook ISBN: 978-3-319-12766-8Published: 12 December 2014

  • Edition Number: 1

  • Number of Pages: XII, 194

  • Number of Illustrations: 9 b/w illustrations, 15 illustrations in colour

  • Topics: Human Genetics, Biochemistry, general, Cell Biology

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